Dacetuzumab

Dacetuzumab ^?
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	CD40
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	880486-59-9^N
ATC code	None
UNII	UT59FF4T5X^Y
Chemical data
Formula	C₆₄₅₂H₉₉₆₄N₁₇₃₂O₁₉₉₈S₄₂
Mol. mass	145.1 kDa (for the peptide)
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Dacetuzumab (also known as SGN-40 or huS2C6) is a humanized monoclonal antibody^[1] being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma^[2] and hematological malignancies.^[3]

This drug was developed by Seattle Genetics, Inc.

References

^ Statement On A Nonproprietary Name Adopted By The USAN Council - Dacetuzumab, American Medical Association.
^ Advani, R.; Forero-torres, A.; Furman, R. R.; Rosenblatt, J. D.; Younes, A.; Ren, H.; Harrop, K.; Whiting, N. et al. (2009). "Phase I Study of the Humanized Anti-CD40 Monoclonal Antibody Dacetuzumab in Refractory or Recurrent Non-Hodgkin's Lymphoma". Journal of Clinical Oncology 27 (26): 4371–4377. doi:10.1200/JCO.2008.21.3017. PMID 19636010. edit
^ Khubchandani; Czuczman, M. S.; Hernandez-Ilizaliturri, F. J. (2009). "Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies". Current opinion in investigational drugs (London, England : 2000) 10 (6): 579–587. PMID 19513947. edit

Monoclonal antibodies for tumors

Tumor ("-t(u[m])-")

Human ("-tumu-")	Adecatumumab • Belimumab • Cixutumumab • Conatumumab • Daratumumab • Drozitumab • Figitumumab • Ganitumab • Glembatumumab vedotin • Intetumumab • Iratumumab • Lexatumumab • Lucatumumab • Mapatumumab • Narnatumab • Necitumumab • Ofatumumab • Olaratumab • Panitumumab • Pritumumab • Radretumab • Rilotumumab • Robatumumab • Teprotumumab • Votumumab • Zalutumumab "-melu-" (melanoma): Flanvotumab

Mouse ("-tumo-")	Altumomab pentetate • Anatumomab mafenatox • Arcitumomab • Bectumomab • Blinatumomab • CC49 • Detumomab • Ibritumomab tiuxetan • Minretumomab • Mitumomab • Moxetumomab pasudotox • Naptumomab estafenatox • Nofetumomab merpentan • Pemtumomab^† • Pintumomab • Racotumomab • Satumomab pendetide • Taplitumomab paptox • Tenatumomab • Tositumomab • 3F8 "-govo-" (ovarian tumor): Abagovomab • Igovomab • Oregovomab "-pro-" (prostate tumor): Capromab pendetide "-colo-" (colonic tumor): Edrecolomab • Nacolomab tafenatox

Chimeric ("-tuxi-")	Amatuximab • Bavituximab • Brentuximab vedotin • Cetuximab • Ensituximab • Girentuximab • Indatuximab ravtansine • Rituximab • Siltuximab • Ublituximab "-mexi-" (melanoma): Ecromeximab

Humanized ("-tuzu-")	Afutuzumab • Alemtuzumab • Bevacizumab • Bivatuzumab mertansine • Cantuzumab mertansine • Cantuzumab ravtansine • Citatuzumab bogatox • Clivatuzumab tetraxetan • Dacetuzumab • Dalotuzumab • Elotuzumab^† • Etaracizumab • Farletuzumab • Ficlatuzumab • Gemtuzumab ozogamicin • Inotuzumab ozogamicin • Labetuzumab • Lintuzumab • Lorvotuzumab mertansine • Matuzumab^§ • Milatuzumab • Nimotuzumab • Onartuzumab • Oportuzumab monatox • Pertuzumab • Sibrotuzumab • Tacatuzumab tetraxetan • Tigatuzumab • Trastuzumab • Tucotuzumab celmoleukin • Veltuzumab

Rat/mouse hybrid ("-tumaxo-")	Catumaxomab • Ertumaxomab

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III