DSIF

DSIF (DRB Sensitivity Inducing Factor) is a factor that can either negatively or positively affect transcription by RNA polymerase II (Pol II). In one case of negative regulation, it can interact with NELF to promote the stalling of Pol II at some genes. This stalling is released by P-TEFb. In humans, DSIF is composed of hSPT4 and hSTP5 (SPT4 and SPT5 are homologues in yeast).[1]

References

  1. ^ Wenzel, Sabine; Schweimer, Kristian; Paul Rösch, Paul; Birgitta M. Wöhrl, Birgitta M. (2008). "The small hSpt4 subunit of the human transcription elongation factor DSIF is a Zn-finger protein with α/β type topology.". Biochemical and Biophysical Research Communications 370 (3): 414–418. doi:10.1016/j.bbrc.2008.03.080. PMID 18373978.