DRG1

Developmentally regulated GTP binding protein 1

Identifiers

DRG1; DKFZp434N1827; NEDD3

External IDs

OMIM: 603952 MGI: 1343297 HomoloGene: 3060 GeneCards: DRG1 Gene

Gene Ontology
Molecular function	• nucleotide binding • protein binding • GTP binding • transcription factor binding
Cellular component	• intracellular • nucleus • cytoplasm • intermediate filament cytoskeleton
Biological process	• transcription, DNA-dependent • multicellular organismal development
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
31.8 – 31.92 Mb

Chr 11:
3.09 – 3.17 Mb

PubMed search

[1]

[2]

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.^[1]^[2]^[3]

References

^ Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem 269 (41): 25447–53. PMID 7929244.
^ Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem Biophys Res Commun 189 (1): 363–70. doi:10.1016/0006-291X(92)91567-A. PMID 1449490.
^ "Entrez Gene: DRG1 developmentally regulated GTP binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4733.

Sazuka T, Kinoshita M, Tomooka Y, et al. (1992). "Expression of DRG during murine embryonic development.". Biochem. Biophys. Res. Commun. 189 (1): 371–7. doi:10.1016/0006-291X(92)91568-B. PMID 1280421.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.". Oncogene 12 (11): 2343–50. PMID 8649774.
Zhao XF, Aplan PD (1999). "SCL binds the human homologue of DRG in vivo.". Biochim. Biophys. Acta 1448 (1): 109–14. PMID 9824680.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins.". Biochim. Biophys. Acta 1491 (1–3): 196–204. PMID 10760581.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bandyopadhyay S, Pai SK, Gross SC, et al. (2003). "The Drg-1 gene suppresses tumor metastasis in prostate cancer". Cancer Res. 63 (8): 1731–6. PMID 12702552.
Bandyopadhyay S, Pai SK, Hirota S, et al. (2004). "Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression". Oncogene 23 (33): 5675–81. doi:10.1038/sj.onc.1207734. PMID 15184886.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bandyopadhyay S, Wang Y, Zhan R, et al. (2007). "The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer". Cancer Res. 66 (24): 11983–90. doi:10.1158/0008-5472.CAN-06-0943. PMID 17178897.

DRG1

References

Further reading