DOK3

Docking protein 3

Identifiers

DOK3; DOKL; FLJ22570; FLJ39939

External IDs

OMIM: 611435 MGI: 1351490 HomoloGene: 8448 GeneCards: DOK3 Gene

Gene Ontology
Molecular function	• insulin receptor binding
Cellular component	• cytoplasm • plasma membrane
Biological process	• Ras protein signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
176.93 – 176.94 Mb

Chr 13:
55.62 – 55.63 Mb

PubMed search

[1]

[2]

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.^[1]^[2]^[3]

References

^ Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85490.
^ Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
^ "Entrez Gene: DOK3 docking protein 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79930.

Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. PMC 84915. PMID 10567556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84915.
Grimm J, Sachs M, Britsch S et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150770.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. doi:10.1128/MCB.24.6.2332-2343.2004. PMC 355862. PMID 14993273. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=355862.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Honma M, Higuchi O, Shirakata M et al. (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells 11 (2): 143–51. doi:10.1111/j.1365-2443.2006.00926.x. PMID 16436051.

DOK3

References

Further reading