Delta-like 1

Delta-like 1 (Drosophila)

Identifiers

DLL1; DELTA1; DL1; Delta

External IDs

OMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1 Gene

Gene Ontology
Molecular function	• Notch binding • calcium ion binding • protein binding
Cellular component	• extracellular region • plasma membrane • integral to plasma membrane • cytoplasmic vesicle
Biological process	• cell fate determination • somite specification • cell communication • Notch signaling pathway • Notch signaling pathway • Notch receptor processing • multicellular organismal development • determination of left/right symmetry • compartment pattern formation • hemopoiesis • cell differentiation • regulation of cell adhesion • negative regulation of cell differentiation • negative regulation of auditory receptor cell differentiation • inner ear development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
170.59 – 170.6 Mb

Chr 17:
15.5 – 15.51 Mb

PubMed search

[1]

[2]

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.^[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.^[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2.^[2]^[3]^[4]

References

^ ^a ^b "Entrez Gene: DLL1 delta-like 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514.
^ Shimizu, K; Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (Jul. 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656.
^ Blaumueller, C M; Qi H, Zagouras P, Artavanis-Tsakonas S (Jul. 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell (UNITED STATES) 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. ISSN 0092-8674. PMID 9244302.
^ Shimizu, K; Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (Sep. 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767.

Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
Lewis AK, Frantz GD, Carpenter DA et al. (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718.
Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
Gray GE, Mann RS, Mitsiadis E et al. (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1866435.
Beckers J, Clark A, Wünsch K et al. (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134.
Morrison A, Hodgetts C, Gossler A et al. (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135.
Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood 95 (5): 1616–25. PMID 10688816.
Shimizu K, Chiba S, Hosoya N et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767.
Shimizu K, Chiba S, Saito T et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Jaleco AC, Neves H, Hooijberg E et al. (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193482.
Shimizu K, Chiba S, Saito T et al. (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125840.
Panin VM, Shao L, Lei L et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
Sakamoto K, Yamaguchi S, Ando R et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150801.
Karlström H, Beatus P, Dannaeus K et al. (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139279.
Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. PMID 12684674.
Six E, Ndiaye D, Laabi Y et al. (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164639.
LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.

Signaling pathway: notch signaling pathway

Receptor on signaling cell	Delta: DLL1 · DLL3 · DLL4

Ligand	Jagged: JAG1 · JAG2

Receptor on receiving cell	NOTCH1 · NOTCH2 · NOTCH3 · NOTCH4

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Delta-like 1

Interactions

References

Further reading