DIDO1

Death inducer-obliterator 1

PDB rendering based on 1wem.
Identifiers
Symbols DIDO1; BYE1; C20orf158; DATF1; DIDO2; DIDO3; DIO-1; DIO1; DKFZp434P1115; FLJ11265; KIAA0333; MGC16140; dJ885L7.8
External IDs OMIM: 604140 MGI: 1344352 HomoloGene: 34139 GeneCards: DIDO1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 11083 23856
Ensembl ENSG00000101191 ENSMUSG00000038914
UniProt Q9BTC0 Q05C59
RefSeq (mRNA) NM_001193369.1 NM_011805
RefSeq (protein) NP_001180298.1 NP_035935
Location (UCSC) Chr 20:
61.51 – 61.57 Mb		 Chr 2:
180.39 – 180.44 Mb
PubMed search [1] [2]

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.[1][2]

Contents

Function

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.[2]

References

  1. ^ Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development". Proc Natl Acad Sci U S A 96 (14): 7992–7. doi:10.1073/pnas.96.14.7992. PMC 22175. PMID 10393935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22175. 
  2. ^ a b "Entrez Gene: DIDO1 death inducer-obliterator 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11083. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.