DHRS4

Dehydrogenase/reductase (SDR family) member 4

Identifiers

DHRS4; CR; FLJ11008; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2

External IDs

OMIM: 611596 MGI: 90169 HomoloGene: 49646 GeneCards: DHRS4 Gene

Gene Ontology
Molecular function	• carbonyl reductase (NADPH) activity • binding • oxidoreductase activity
Cellular component	• mitochondrion • mitochondrion • peroxisome • nuclear membrane • intracellular membrane-bounded organelle
Biological process	• oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000157326

ENSMUSG00000022210

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
24.42 – 24.44 Mb

Chr 14:
56.1 – 56.11 Mb

PubMed search

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.^[1]^[2]^[3]

References

^ Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J 340 ( Pt 2) (Pt 2): 561–8. PMC 1220285. PMID 10333503. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220285.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896744.
^ "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10901.

Further reading

Song XH, Liang B, Liu GF et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Du J, Huang DY, Liu GF et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao 31 (7): 661–7. PMID 15473316.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.