DEFA6
Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.[1][2] DEFA6 is expressed in the Paneth cells of the ileum.[3]
Function
The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 was reported to possess poor antibacterial potency.[4]
Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.[1]
References
Further reading
- Szyk A, Wu Z, Tucker K, et al. (2006). "Crystal structures of human α-defensins HNP4, HD5, and HD6". Protein Sci. 15 (12): 2749–60. doi:10.1110/ps.062336606. PMC 2242434. PMID 17088326. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2242434.
- Wu Z, Ericksen B, Tucker K, et al. (2004). "Synthesis and characterization of human alpha-defensins 4-6". J Pept Res. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
- Mallow EB, Harris A, Salzman N, et al. (1996). "Human enteric defensins. Gene structure and developmental expression". J. Biol. Chem. 271 (8): 4038–45. doi:10.1074/jbc.271.8.4038. PMID 8626737.
- Bevins CL, Jones DE, Dutra A, et al. (1996). "Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships". Genomics 31 (1): 95–106. doi:10.1006/geno.1996.0014. PMID 8808285.
- Eisenhauer PB, Harwig SS, Lehrer RI (September 1992). "Cryptdins: antimicrobial defensins of the murine small intestine". Infect. Immun. 60 (9): 3556–65. PMC 257361. PMID 1500163. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=257361.
- Huttner KM, Selsted ME, Ouellette AJ (February 1994). "Structure and diversity of the murine cryptdin gene family". Genomics 19 (3): 448–53. doi:10.1006/geno.1994.1093. PMID 8188287.
PDB gallery
|
|
|
1zmq: Crystal structure of human alpha-defensin-6
|
|
|
|