| Dynactin 5 (p25) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | DCTN5; | ||||||||||
| External IDs | OMIM: 612962 HomoloGene: 10998 GeneCards: DCTN5 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 84516 | 59288 | |||||||||
| Ensembl | ENSG00000166847 | ENSMUSG00000030868 | |||||||||
| UniProt | Q9BTE1 | Q9QZB9 | |||||||||
| RefSeq (mRNA) | n/a | NM_021608.3 | |||||||||
| RefSeq (protein) | n/a | NP_067621.3 | |||||||||
| Location (UCSC) | Chr 16: 23.65 – 23.68 Mb |
Chr 7: 129.28 – 129.29 Mb |
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| PubMed search | [1] | [2] | |||||||||
Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.[1]
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[1]
Eckley, D. M.; Gill, S. R.; Melkonian, K. A.; Bingham, J. B.; Goodson, H. V.; Heuser, J. E.; Schroer, T. A. (1999). "Analysis of Dynactin Subcomplexes Reveals a Novel Actin-Related Protein Associated with the Arp1 Minifilament Pointed End". The Journal of cell biology 147 (2): 307–320. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174220. Parisi, G.; Fornasari, M.; Echave, J. (2004). "Dynactins p25 and p27 are predicted to adopt the L?H fold". FEBS Letters 562 (1–3): 1–4. doi:10.1016/S0014-5793(04)00165-6. PMID 15043994. Burton, P. R.; Clayton, D. G.; Cardon, L. R.; Craddock, N.; Deloukas, P.; Duncanson, A.; Kwiatkowski, D. P.; McCarthy, M. I. et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature 447 (7145): 661–678. doi:10.1038/nature05911. PMC 2719288. PMID 17554300. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2719288.