DCC1

Defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

Identifiers

DSCC1; DCC1; MGC5528

External IDs

OMIM: 613203 MGI: 1919357 HomoloGene: 5464 GeneCards: DSCC1 Gene

Gene Ontology
Molecular function	• DNA binding • protein binding
Cellular component	• chromosome, centromeric region • chromatin • nucleus • nucleoplasm
Biological process	• regulation of DNA replication • cell cycle • maintenance of mitotic sister chromatid cohesion • post-translational protein acetylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000136982

ENSMUSG00000022422

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
120.85 – 120.87 Mb

Chr 15:
54.91 – 54.92 Mb

PubMed search

Sister chromatid cohesion protein DCC1 is a protein that in humans is encoded by the DSCC1 gene.^[1]^[2]

Interactions

DCC1 has been shown to interact with CHTF18.^[1]^[3]

References

^ ^a ^b Merkle CJ, Karnitz LM, Henry-Sanchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J Biol Chem 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
^ "Entrez Gene: DCC1 defective in sister chromatid cohesion homolog 1 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79075.
^ Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep. 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. doi:10.1073/pnas.1434308100. ISSN 0027-8424. PMC 193545. PMID 12930902. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193545.

Further reading

Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bermudez VP, Maniwa Y, Tappin I, et al. (2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193545.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.