DAPP1

Dual adaptor of phosphotyrosine and 3-phosphoinositides

PDB rendering based on 1fao.

Available structures
PDB	1FAO, 1FB8

Identifiers

DAPP1; BAM32; DKFZp667E0716

External IDs

OMIM: 605768 MGI: 1347063 HomoloGene: 32138 GeneCards: DAPP1 Gene

Gene Ontology
Molecular function	• protein tyrosine phosphatase activity • phospholipid binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• cytoplasm • plasma membrane
Biological process	• protein dephosphorylation • signal transduction • peptidyl-tyrosine dephosphorylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000070190

ENSMUSG00000028159

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
100.74 – 100.79 Mb

Chr 3:
137.59 – 137.64 Mb

PubMed search

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.^[1]^[2]

References

^ Dowler S, Currie RA, Downes CP, Alessi DR (Oct 1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides". Biochem J 342 ( Pt 1): 7–12. PMC 1220429. PMID 10432293. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220429.
^ "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27071.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Marshall AJ, Niiro H, Lerner CG, et al. (2000). "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.". J. Exp. Med. 191 (8): 1319–32. doi:10.1084/jem.191.8.1319. PMC 2193139. PMID 10770799. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193139.
Dowler S, Montalvo L, Cantrell D, et al. (2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.". Biochem. J. 349 (Pt 2): 605–10. doi:10.1042/0264-6021:3490605. PMC 1221184. PMID 10880360. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221184.
Ferguson KM, Kavran JM, Sankaran VG, et al. (2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.". Mol. Cell 6 (2): 373–84. doi:10.1016/S1097-2765(00)00037-X. PMID 10983984.
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221362.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Stephens LR, Anderson KE, Hawkins PT (2001). "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.". J. Biol. Chem. 276 (46): 42767–73. doi:10.1074/jbc.M107194200. PMID 11524430.
Niiro H, Maeda A, Kurosaki T, Clark EA (2002). "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival.". J. Exp. Med. 195 (1): 143–9. doi:10.1084/jem.20011524. PMC 2196019. PMID 11781373. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196019.
Marshall AJ, Krahn AK, Ma K, et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133950.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Han A, Saijo K, Mecklenbräuker I, et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.". Immunity 19 (4): 621–32. doi:10.1016/S1074-7613(03)00275-9. PMID 14563325.
Allam A, Niiro H, Clark EA, Marshall AJ (2004). "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.". J. Biol. Chem. 279 (38): 39775–82. doi:10.1074/jbc.M403367200. PMID 15247305.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Niiro H, Allam A, Stoddart A, et al. (2004). "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.". J. Immunol. 173 (9): 5601–9. PMID 15494510.

PDB gallery

1fao: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE

1fb8: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH