Cripto

cripto

Solution structure of mouse Cripto CFC domain.[1]
Identifiers
Symbols CFC1B; MGC133213; HTX2; CRYPTIC; FLJ77897
External IDs OMIM: 605194 HomoloGene: 50007 GeneCards: CFC1B Gene
Orthologs
Species Human Mouse
Entrez 653275 12627
Ensembl ENSG00000152093 ENSMUSG00000026124
UniProt P0CG36 P97766
RefSeq (mRNA) NM_032545 NM_007685
RefSeq (protein) NP_115934 NP_031711
Location (UCSC) Chr 2:
131.07 – 131.07 Mb		 Chr 1:
34.59 – 34.6 Mb
PubMed search [1] [2]

Cryptic family protein 1B is a protein that in humans is encoded by the CFC1B gene.[2][3] Cryptic family protein 1B acts as a receptor for the TGF beta signaling pathway.

Cryptic is a glycosylphosphatidylinositol-anchored coreceptor that binds nodal and the activin type I (ALK)-4 receptor (ALK4).[4]

Contents

Structure

Cripto is composed of two adjacent cysteine-rich motifs, the EGF-like and the CFC, of a N-terminal signal peptide and of a C-terminal hydrophobic region attached by a GPI anchor.[1]

NMR data confirm that the CFC domain has a C1-C4, C2-C6, C3-C5 disulfide pattern and show that structures are rather flexible and globally extended, with three noncanonical antiparallel strands.[1]

Clinical significance

CFC1B has oncogene potential.[1] Furthermore the cryptic protein is highly overexpressed in many tumors.[1]

Cripto is one of the key regulators of embryonic stem cells differentiation into cardiomyocyte vs neuronal fate.[5]

References

  1. ^ a b c d e Calvanese L, Saporito A, Marasco D, et al. (November 2006). "Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala". J. Med. Chem. 49 (24): 7054–62. doi:10.1021/jm060772r. PMID 17125258. 
  2. ^ "Entrez Gene: cripto". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653275. 
  3. ^ Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  4. ^ Lonardo E, Parish CL, Ponticelli S, et al. (August 2010). "A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease". Stem Cells 28 (8): 1326–37. doi:10.1002/stem.458. PMID 20641036. 
  5. ^ Chambery A, Vissers JP, Langridge JI, et al. (February 2009). "Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis". J. Proteome Res. 8 (2): 1047–58. doi:10.1021/pr800485c. PMID 19152270. 

External links

TGF beta superfamily of ligands
TGF beta receptors
(Activin, BMP)
Transducers/SMAD
Ligand inhibitors
Cerberus · Chordin · DAN · Decorin · Follistatin · Gremlin · Lefty · LTBP1 · Noggin · THBS1
Coreceptors
BAMBI · Cripto
Other
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)