Coatlaxopeuh is a word proposed by Mariano Rojas as a possible Nahuatl origin of the word Guadelupe.
Gloria Anzaldúa, in her book Borderlands / La Frontera, translates the name Coatlalopeuh as "She Who Has Dominion over Serpents." Because Coatlalopeuh sounds like Guadalupe, the Spanish saw Coatlalopeuh as parallel or identical to "the dark Virgin, Guadalupe, patroness of West Central Spain" (Page 27). Anzaldúa gives Coatlaxopeuh as a variant name. She sees both versions as being linked historically to Coatlicue, whose name means "Serpent Skirt."