Clorexolone

Clorexolone

Systematic (IUPAC) name
6-chloro-2-cyclohexyl-3-oxo-2,3-dihydro- 1H-isoindole-5-sulfonamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	2127-01-7
ATC code	C03BA12
PubChem	CID 16473
ChemSpider	15615
UNII	Q2PLT3FS05^Y
KEGG	D01436
Chemical data
Formula	C₁₄H₁₇Cl N₂O₃S
Mol. mass	328.814 g/mol
SMILES	eMolecules & PubChem

Clorexolone is a low-ceiling sulfonamide diuretic.

Antihypertensives: diuretics (C03)

Sulfonamides
(except EA)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# • Bumetanide • Torasemide • Etacrynic acid

Thiazides (Na-Cl at DCT, Calcium-sparing)	Hydrochlorothiazide^# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide

Thiazide-likes (primarily DCT)	Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# • Triamterene • Benzamil

Aldosterone antagonists	Spironolactone^# • Eplerenone • Potassium canrenoate • Canrenone

Osmotic diuretics (PT, DL)

Mannitol^# • Urea

VAs (DCT and CD)

vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan

tetracyclines: Demeclocycline

Other

mercurial diuretic (Mersalyl) • Theobromine • Cicletanine

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)