Clofoctol

Clofoctol
Systematic (IUPAC) name
2-[(2,4-dichlorophenyl)methyl]-
4-(2,4,4-trimethylpentan-2-yl)phenol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Rectal (suppository)[1][2]
Pharmacokinetic data
Bioavailability 98%[1]
Metabolism Hepatic glucuronidation[1]
Excretion Biliary[1]
Identifiers
CAS number 37693-01-9
ATC code J01XX03
PubChem CID 2799
ChemSpider 2697 Y
UNII 704083NI0R Y
KEGG D07244 Y
Chemical data
Formula C21H26Cl2O 
Mol. mass 365.336 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1][2]

It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.[3]

It penetrates into human lung tissue.[4]

References

  1. ^ a b c d e "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm. Retrieved 2007-08-10. 
  2. ^ a b "Clofoctol" (in French). BIAM. July 16, 1999. http://www.biam2.org/www/Sub3508.html. Retrieved 2007-08-10. 
  3. ^ Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]" (in French). J Pharmacol 11 (4): 411–25. PMID 6782374. 
  4. ^ Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res 14 (1): 39–43. PMID 3391105. 
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