Clodronic acid

Clodronic acid

Systematic (IUPAC) name
(dichloro-phosphono-methyl)phosphonic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	10596-23-3^Y
ATC code	M05BA02
PubChem	CID 25419
DrugBank	APRD00639
ChemSpider	23731^Y
UNII	0813BZ6866^Y
KEGG	D03545^Y
ChEBI	CHEBI:110423^Y
ChEMBL	CHEMBL12318^Y
Chemical data
Formula	C H₄Cl₂O₆P₂
Mol. mass	244.892 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)^Y Key:ACSIXWWBWUQEHA-UHFFFAOYSA-N^Y
N(what is this?) (verify)

Clodronic acid (INN) or clodronate disodium (USAN) is a bisphosphonate. It is used in experimental medicine to selectively deplete for macrophages. It is also approved for human use in Canada and Australia, the United Kingdom and Italy, where it is marketed as Bonefos, Loron and Clodron and prescribed as a bone resorption inhibitor and antihypercalcemic agent.

Drugs for treatment of bone diseases (M05)

Bisphosphonates

Nitrogenous (Alendronic acid, ibandronic acid, incadronic acid, pamidronic acid, risedronic acid, zoledronic acid)
Non-nitrogenous (Etidronic acid, clodronic acid, tiludronic acid)

Bone morphogenetic proteins

Dibotermin alfa • Eptotermin alfa

Other

Resorption inhibitor (Ipriflavone) • Aluminium chlorohydrate • Dual action bone agent (Strontium ranelate) •
RANKL inhibitor (Denosumab) • Cathepsin K inhibitor (Odanacatib)

M: BON/CAR

anat(c/f/k/f, u, t/p, l)/phys/devp/cell

noco/cong/tumr, sysi/epon, injr

proc, drug(M5)