Chakragati mouse

Chakragati mouse (ckr) is an insertional transgenic mouse mutant displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition, latent inhibition[1] and has brain abnormalities such as lateral ventricular enlargement[2] that are typical to endophenotypic models of schizophrenia, which make it useful in screening for antipsychotic drug candidates.[3] The mouse is currently licensed by Chakra Biotech.

References

  1. ^ Verma V, Tan CH, Ong WY, et al. (March 2008). "The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition". Neurosci. Res. 60 (3): 281–8. doi:10.1016/j.neures.2007.11.007. PMID 18164085. http://linkinghub.elsevier.com/retrieve/pii/S0168-0102(07)01834-2. 
  2. ^ Torres G, Meeder BA, Hallas BH et al. (2005). "Ventricular size mapping in a transgenic model of schizophrenia". Developmental Brain Research 154 (1): 35–44. doi:10.1016/j.devbrainres.2004.08.011. PMID 15617753. 
  3. ^ Dawe GS, Ratty AK (2007). "The chakragati mouse: A mouse model for rapid in vivo screening of antipsychotic drug candidates". Biotechnology Journal 2 (11): 1344–52. doi:10.1002/biot.200700145. PMID 17886239. 

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