Cefroxadine

Cefroxadine
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Pharmacokinetic data
Half-life ~1 hour
Excretion Renal
Identifiers
CAS number 51762-05-1
ATC code J01DB11
PubChem CID 443991
ChemSpider 4447587
UNII B908C4MV2R Y
KEGG D01528
Chemical data
Formula C16H19N3O5S 
Mol. mass 365.405 g/mol
SMILES eMolecules & PubChem

Cefroxadine (INN, trade names Oraspor and Cefthan-DS) is a cephalosporin antibiotic. It is structurally related to cefalexin, and both drugs share a similar spectrum of activity.[1]

It is available in Italy.[2]

References

  1. ^ Yasuda K, Kurashige S, Mitsuhashi S (July 1980). "Cefroxadine (CGP-9000), an orally active cephalosporin". Antimicrobial Agents and Chemotherapy 18 (1): 105–10. PMC 283947. PMID 6998373. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=283947. 
  2. ^ [No authors listed]. "Oraspor" (in Italian). Prontuario.it. Elsevier. http://www.prontuario.it/ORASPOR/?f=xuiqqmolyaqmxu. Retrieved 2010-07-31. 
Intracellular
inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin) • DADAL/AR inhibitors (Cycloserine) • bactoprenol inhibitors (Bacitracin)
Glycopeptide
inhibit PG chain elongation: Vancomycin# (Oritavancin, Telavancin) • Teicoplanin (Dalbavancin) • Ramoplanin
β-lactams/
(inhibit PBP
cross-links)
Cefazolin# • Cefacetrile • Cefadroxil • Cefalexin • Cefaloglycin • Cefalonium • Cefaloridine • Cefalotin • Cefapirin • Cefatrizine • Cefazedone • Cefazaflur • Cefradine • Cefroxadine • Ceftezole
Combinations
Other

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)