Casamino acid

Casamino acids is a mixture of amino acids and some very small peptides obtained from acid hydrolysis of casein [1] It is typically used in microbial growth media. It has all the essential amino acids except tryptophan which becomes almost completely destroyed when digested with sulfuric or hydrochloric acid.[1]

Casamino acids are similar to tryptone, the latter differing by being an incomplete enzymatic hydrolysis with some oligopeptides present, while casamino acids predominantly free amino acids.

Uses

Casamino acids are either found in the Daptacel brand DTaP vaccine or used in its manufacture.[2]

Reference

  1. ^ a b Mueller, J. Howard; Johnson, Everett R (1 Jan 1941 .). "Acid Hydrolysates of Casein to Replace Peptone in the Preparation of Bacteriological Media". The Journal of Immunology 40 (1): 33–38. ISSN 1550-6606. 
  2. ^ http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf