Canrenone

Canrenone

Systematic (IUPAC) name
10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	95%
Half-life	10-35 hours
Identifiers
CAS number	976-71-6^N
ATC code	C03DA03
PubChem	CID 13789
ChemSpider	13192^Y
UNII	78O20X9J0U^Y
ChEMBL	CHEMBL42874^N
Chemical data
Formula	C₂₂H₂₈O₃
Mol. mass	340.456 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1^Y Key:UJVLDDZCTMKXJK-WNHSNXHDSA-N^Y
N(what is this?) (verify)

Canrenone (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.^[1]

It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.

References

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# • Bumetanide • Torasemide • Etacrynic acid

Thiazides (Na-Cl at DCT, Calcium-sparing)	Hydrochlorothiazide^# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide

Thiazide-likes (primarily DCT)	Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone

ESC blockers	Amiloride^# • Triamterene • Benzamil

Aldosterone antagonists	Spironolactone^# • Eplerenone • Potassium canrenoate • Canrenone

tetracyclines: Demeclocycline

Other

mercurial diuretic (Mersalyl) • Theobromine • Cicletanine

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

Agonist

AC-262,356^§ • Andarine (S-4)^§ • BMS-564,929^§ • LGD-2226^§ • LGD-3303^§ • Ostarine (MK-2866)^§ • S-23^§ • S-40503^§

5α-reductase inhibitors	Alfatradiol • Bexlosteride • Dutasteride • Epristeride • Finasteride • Izonsteride • Lapisteride • Turosteride

CYP17A1 inhibitors	Abiraterone • Galeterone^§ • Ketoconazole

M: ♂ MRS

anat/phys/devp

noco/cong/tumr, sysi/epon

proc, drug (G3B/4BE/4C)