CYP4F3
Leukotriene-B(4) omega-hydroxylase 2 is an enzyme that in humans is encoded by the CYP4F3 gene.[1][2][3]
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away.[3]
References
- ^ Kikuta Y, Kusunose E, Endo K, Yamamoto S, Sogawa K, Fujii-Kuriyama Y, Kusunose M (Jun 1993). "A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase". J Biol Chem 268 (13): 9376–80. PMID 8486631.
- ^ Kikuta Y, Kato M, Yamashita Y, Miyauchi Y, Tanaka K, Kamada N, Kusunose M (Apr 1998). "Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization". DNA Cell Biol 17 (3): 221–30. doi:10.1089/dna.1998.17.221. PMID 9539102.
- ^ a b "Entrez Gene: CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4051.
Further reading
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family". Gen. Pharmacol. 28 (3): 351–9. doi:10.1016/S0306-3623(96)00246-7. PMID 9068972.
- Kikuta Y, Kusunose E, Kondo T, et al. (1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver". FEBS Lett. 348 (1): 70–4. doi:10.1016/0014-5793(94)00587-7. PMID 8026587.
- Christmas P, Ursino SR, Fox JW, Soberman RJ (1999). "Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase". J. Biol. Chem. 274 (30): 21191–9. doi:10.1074/jbc.274.30.21191. PMID 10409674.
- Christmas P, Jones JP, Patten CJ, et al. (2001). "Alternative splicing determines the function of CYP4F3 by switching substrate specificity". J. Biol. Chem. 276 (41): 38166–72. doi:10.1074/jbc.M104818200. PMID 11461919.
- Christmas P, Carlesso N, Shang H, et al. (2003). "Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter". J. Biol. Chem. 278 (27): 25133–42. doi:10.1074/jbc.M302106200. PMID 12709424.
- Mizukami Y, Sumimoto H, Takeshige K (2004). "Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells". Biochem. Biophys. Res. Commun. 314 (1): 104–9. doi:10.1016/j.bbrc.2003.12.062. PMID 14715252.
- Christmas P, Tolentino K, Primo V, et al. (2006). "Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4". J. Biol. Chem. 281 (11): 7189–96. doi:10.1074/jbc.M513101200. PMID 16380383.
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| CYP1 |
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| CYP2 |
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| CYP3 (CYP3A) |
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| CYP4 |
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| CYP5-20 |
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| CYP21-51 |
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