CYP4F2
Leukotriene-B(4) omega-hydroxylase 1 is an enzyme that in humans is encoded by the CYP4F2 gene.[1][2][3]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.[3]
References
- ^ Chen L, Hardwick JP (Feb 1993). "Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors". Arch Biochem Biophys 300 (1): 18–23. doi:10.1006/abbi.1993.1003. PMID 8424651.
- ^ Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M (Aug 1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver". FEBS Lett 348 (1): 70–4. doi:10.1016/0014-5793(94)00587-7. PMID 8026587.
- ^ a b "Entrez Gene: CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8529.
Further reading
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family.". Gen. Pharmacol. 28 (3): 351–9. doi:10.1016/S0306-3623(96)00246-7. PMID 9068972.
- Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.". J. Pharmacol. Exp. Ther. 285 (3): 1327–36. PMID 9618440.
- Kikuta Y, Miyauchi Y, Kusunose E, Kusunose M (1999). "Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.". DNA Cell Biol. 18 (9): 723–30. doi:10.1089/104454999315006. PMID 10492403.
- Lasker JM, Chen WB, Wolf I, et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11.". J. Biol. Chem. 275 (6): 4118–26. doi:10.1074/jbc.275.6.4118. PMID 10660572.
- Zhang X, Chen L, Hardwick JP (2000). "Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.". Arch. Biochem. Biophys. 378 (2): 364–76. doi:10.1006/abbi.2000.1836. PMID 10860554.
- Zhang X, Hardwick JP (2001). "Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.". Biochem. Biophys. Res. Commun. 279 (3): 864–71. doi:10.1006/bbrc.2000.4020. PMID 11162441.
- Peng X, Pan X, Kenga M (2002). "[Isolation and sequencing of a novel form of cytochrome p-450 4F family from human liver]". Zhonghua Yi Xue Za Zhi 79 (11): 860–2. PMID 11715494.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Nagata T, Takahashi Y, Ishii Y, et al. (2004). "Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array.". Int. J. Mol. Med. 11 (6): 713–21. PMID 12736711.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Hsu MH, Savas U, Griffin KJ, Johnson EF (2007). "Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.". J. Biol. Chem. 282 (8): 5225–36. doi:10.1074/jbc.M608176200. PMID 17142457.
- Sontag TJ, Parker RS (2007). "Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase.". J. Lipid Res. 48 (5): 1090–8. doi:10.1194/jlr.M600514-JLR200. PMID 17284776.
- Stec DE, Roman RJ, Flasch A, Rieder MJ (2007). "Functional polymorphism in human CYP4F2 decreases 20-HETE production.". Physiol. Genomics 30 (1): 74–81. doi:10.1152/physiolgenomics.00003.2007. PMID 17341693.
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CYP1 |
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CYP2 |
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CYP3 (CYP3A) |
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CYP4 |
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CYP5-20 |
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CYP21-51 |
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