CYP4F2

Cytochrome P450, family 4, subfamily F, polypeptide 2
Identifiers
Symbols CYP4F2; CPF2
External IDs OMIM604426 MGI2158641 HomoloGene80199 GeneCards: CYP4F2 Gene
EC number 1.14.13.30
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8529 106648
Ensembl ENSG00000186115 ENSMUSG00000073424
UniProt P78329 n/a
RefSeq (mRNA) NM_001082 NM_134127.1
RefSeq (protein) NP_001073 NP_598888.1
Location (UCSC) Chr 19:
15.99 – 16.01 Mb
Chr 17:
32.82 – 32.84 Mb
PubMed search [1] [2]

Leukotriene-B(4) omega-hydroxylase 1 is an enzyme that in humans is encoded by the CYP4F2 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.[3]

References

  1. ^ Chen L, Hardwick JP (Feb 1993). "Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors". Arch Biochem Biophys 300 (1): 18–23. doi:10.1006/abbi.1993.1003. PMID 8424651. 
  2. ^ Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M (Aug 1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver". FEBS Lett 348 (1): 70–4. doi:10.1016/0014-5793(94)00587-7. PMID 8026587. 
  3. ^ a b "Entrez Gene: CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8529. 

Further reading