CYP4A22

cytochrome P450, family 4, subfamily A, polypeptide 22

Identifiers

External IDs

MGI: 88612 HomoloGene: 107112 GeneCards: CYP4A22 Gene

1.14.15.3

Gene Ontology
Molecular function	• electron carrier activity • metal ion binding • heme binding • iron ion binding • monooxygenase activity • alkane 1-monooxygenase activity
Cellular component	• membrane • endoplasmic reticulum • microsome • extrinsic to membrane • endoplasmic reticulum membrane
Biological process	• oxidation reduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
47.38 – 47.39 Mb

Chr 4:
115.08 – 115.11 Mb

PubMed search

[1]

[2]

CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.^[2]

References

^ Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M (July 2006). "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutat. Res. 599 (1–2): 98–104. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.
^ "Entrez Gene: CYP4A22". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284541.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bellamine A, Wang Y, Waterman MR, et al. (2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Arch. Biochem. Biophys. 409 (1): 221–7. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262.
Gainer JV, Bellamine A, Dawson EP, et al. (2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1	A1 · A2 · B1

CYP2	A6 · A7 · A13 · B6 · C8 · C9 · C18 · C19 · D6 · E1 · F1 · J2 · R1 · S1 · U1 · W1

CYP3 (CYP3A)	A4 · A5 · A7 · A43

CYP4	A11 · A22 · B1 · F2 · F3 · F8 · F11 · F12 · F22 · V2 · X1 · Z1

CYP5-20	CYP5 (A1) · CYP7 (A1, B1) · CYP8 (A1, B1) · CYP11 (A1, B1, B2) · CYP17 (A1) · CYP19 (A1) · CYP20 (A1)

CYP21-51	CYP21 (A2) · CYP24 (A1) · CYP26 (A1, B1, C1) · CYP27 (A1, B1, C1) · CYP39 (A1) · CYP46 (A1) · CYP51 (A1)

CYP4A22

References

Further reading