CYP26C1

Cytochrome P450, family 26, subfamily C, polypeptide 1

Identifiers

External IDs

OMIM: 608428 MGI: 2679699 HomoloGene: 28089 GeneCards: CYP26C1 Gene

1.14.-.-

Gene Ontology
Molecular function	• retinoic acid binding • retinoic acid 4-hydroxylase activity • retinoic acid 4-hydroxylase activity • electron carrier activity • heme binding • metal ion binding
Cellular component	• endoplasmic reticulum membrane • microsome • membrane • integral to membrane
Biological process	• xenobiotic metabolic process • central nervous system development • anterior/posterior pattern formation • neural crest cell development • retinoic acid catabolic process • organelle fusion • negative regulation of retinoic acid receptor signaling pathway • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
94.82 – 94.83 Mb

Chr 19:
37.76 – 37.77 Mb

PubMed search

[1]

[2]

CYP26C1 (cytochrome P450, family 26, subfamily c, polypeptide 1) is a protein which in humans is encoded by the CYP26C1 gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.^[2]

References

^ Taimi M, Helvig C, Wisniewski J, et al. (January 2004). "A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid". J. Biol. Chem. 279 (1): 77–85. doi:10.1074/jbc.M308337200. PMID 14532297.
^ "Entrez Gene: CYP26C1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=340665.

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Rat E, Billaut-Laden I, Allorge D, et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.". Birth Defects Res. Part a Clin. Mol. Teratol. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
Wan C, Shi Y, Zhao X, et al. (2009). "Positive association between ALDH1A2 and schizophrenia in the Chinese population.". Prog. Neuropsychopharmacol. Biol. Psychiatry 33 (8): 1491–5. doi:10.1016/j.pnpbp.2009.08.008. PMID 19703508.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1380225.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1	A1 · A2 · B1

CYP2	A6 · A7 · A13 · B6 · C8 · C9 · C18 · C19 · D6 · E1 · F1 · J2 · R1 · S1 · U1 · W1

CYP3 (CYP3A)	A4 · A5 · A7 · A43

CYP4	A11 · A22 · B1 · F2 · F3 · F8 · F11 · F12 · F22 · V2 · X1 · Z1

CYP5-20	CYP5 (A1) · CYP7 (A1, B1) · CYP8 (A1, B1) · CYP11 (A1, B1, B2) · CYP17 (A1) · CYP19 (A1) · CYP20 (A1)

CYP21-51	CYP21 (A2) · CYP24 (A1) · CYP26 (A1, B1, C1) · CYP27 (A1, B1, C1) · CYP39 (A1) · CYP46 (A1) · CYP51 (A1)

CYP26C1

References

Further reading