CYP20A1

Cytochrome P450, family 20, subfamily A, polypeptide 1
Identifiers
Symbols CYP20A1; CYP-M; MGC22229
External IDs MGI1925201 HomoloGene18584 GeneCards: CYP20A1 Gene
EC number 1.14.-.-
Orthologs
Species Human Mouse
Entrez 57404 77951
Ensembl ENSG00000119004 ENSMUSG00000049439
UniProt Q6UW02 Q8BKE6
RefSeq (mRNA) NM_177538 NM_030013.2
RefSeq (protein) NP_803882 NP_084289.1
Location (UCSC) Chr 2:
204.1 – 204.16 Mb
Chr 1:
60.4 – 60.44 Mb
PubMed search [1] [2]

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.[2]

References

  1. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
  2. ^ "Entrez Gene: CY20A1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57404. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.