CYFIP1

Cytoplasmic FMR1 interacting protein 1

Identifiers

CYFIP1; FLJ45151; P140SRA-1; SHYC; SRA1

External IDs

OMIM: 606322 MGI: 1338801 HomoloGene: 22628 GeneCards: CYFIP1 Gene

Gene Ontology
Molecular function	• protein binding • Rac GTPase binding • actin filament binding
Cellular component	• ruffle • cytoplasm • mRNA cap binding complex • synaptosome • lamellipodium • cell junction • synapse • perinuclear region of cytoplasm
Biological process	• multicellular organismal development • nervous system development • regulation of cell shape • lamellipodium assembly • cell differentiation • ruffle organization • axon extension
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000068793

ENSMUSG00000030447

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
22.89 – 23.01 Mb

Chr 7:
63.1 – 63.19 Mb

PubMed search

Cytoplasmic FMR1-interacting protein 1 is a protein that in humans is encoded by the CYFIP1 gene.^[1]^[2]

Interactions

CYFIP1 has been shown to interact with FXR2^[1] and FMR1.^[1]

References

^ ^a ^b ^c Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proc Natl Acad Sci U S A 98 (15): 8844–9. doi:10.1073/pnas.151231598. PMC 37523. PMID 11438699. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37523.
^ "Entrez Gene: CYFIP1 cytoplasmic FMR1 interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23191.

Further reading

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Kobayashi K, Kuroda S, Fukata M, et al. (1998). "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.". J. Biol. Chem. 273 (1): 291–5. doi:10.1074/jbc.273.1.291. PMID 9417078.
Witke W, Podtelejnikov AV, Di Nardo A, et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.". EMBO J. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170446.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chai JH, Locke DP, Greally JM, et al. (2003). "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.". Am. J. Hum. Genet. 73 (4): 898–925. doi:10.1086/378816. PMC 1180611. PMID 14508708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180611.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kawano Y, Yoshimura T, Tsuboi D, et al. (2005). "CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.". Mol. Cell. Biol. 25 (22): 9920–35. doi:10.1128/MCB.25.22.9920-9935.2005. PMC 1280248. PMID 16260607. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1280248.
Bittel DC, Kibiryeva N, Butler MG (2006). "Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.". Pediatrics 118 (4): e1276–83. doi:10.1542/peds.2006-0424. PMID 16982806.