CYB5R4

Cytochrome b5 reductase 4

Identifiers

CYB5R4; NCB5OR; RP4-676J13.1; cb5/cb5R; dJ676J13.1

External IDs

OMIM: 608343 MGI: 2386848 HomoloGene: 69207 GeneCards: CYB5R4 Gene

1.6.2.2

Gene Ontology
Molecular function	• cytochrome-b5 reductase activity • NAD(P)H oxidase activity • NAD(P)H oxidase activity • oxidoreductase activity • oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor • heme binding • metal ion binding
Cellular component	• endoplasmic reticulum • perinuclear region of cytoplasm
Biological process	• detection of oxygen • generation of precursor metabolites and energy • superoxide metabolic process • insulin secretion • glucose homeostasis • response to antibiotic • cell development • oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
84.57 – 84.67 Mb

Chr 9:
86.92 – 86.97 Mb

PubMed search

[1]

[2]

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.^[1]^[2]

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]^[2]

References

^ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24718.
^ ^a ^b "Entrez Gene: CYB5R4 cytochrome b5 reductase 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51167.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Zhu H, Larade K, Jackson TA, et al. (2004). "NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.". J. Biol. Chem. 279 (29): 30316–25. doi:10.1074/jbc.M402664200. PMC 3045664. PMID 15131110. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3045664.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Andersen G, Wegner L, Rose CS, et al. (2005). "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus". Diabetes 53 (11): 2992–7. doi:10.2337/diabetes.53.11.2992. PMC 3044473. PMID 15504981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3044473.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.

CYB5R4

References

Further reading