CYB5R2

cytochrome b5 reductase 2

Identifiers

External IDs

OMIM: 608342 MGI: 2444415 HomoloGene: 6182 GeneCards: CYB5R2 Gene

Gene Ontology
Molecular function	• electron carrier activity • cytochrome-b5 reductase activity • oxidoreductase activity
Cellular component	• membrane • soluble fraction
Biological process	• sterol biosynthetic process • oxidation reduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000166394

ENSMUSG00000048065

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
7.64 – 7.65 Mb

Chr 7:
114.89 – 114.9 Mb

PubMed search

Cytochrome b5 reductase 2 is an enzyme that in humans is encoded by the CYB5R2 gene.^[1]^[2]

References

^ "Entrez Gene: cytochrome b5 reductase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51700.
^ Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (December 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24718.

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Heard-Costa NL, Zillikens MC, Monda KL, et al. (2009). Dermitzakis, Emmanouil T.. ed. "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium". PLoS Genet. 5 (6): e1000539. doi:10.1371/journal.pgen.1000539. PMC 2695005. PMID 19557197. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2695005.
Zhu H, Qiu H, Yoon HW, et al. (1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24718.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Baker MA, Krutskikh A, Curry BJ, et al. (2005). "Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa". Biol. Reprod. 73 (2): 334–42. doi:10.1095/biolreprod.104.037960. PMID 15858218.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.