| Chemokine (C-X-C motif) ligand 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CXCL9; CMK; Humig; MIG; SCYB9; crg-10 | ||||||||||||
| External IDs | OMIM: 601704 MGI: 1352449 HomoloGene: 1813 GeneCards: CXCL9 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4283 | 17329 | |||||||||||
| Ensembl | ENSG00000138755 | ENSMUSG00000029417 | |||||||||||
| UniProt | Q07325 | n/a | |||||||||||
| RefSeq (mRNA) | NM_002416.1 | NM_008599.4 | |||||||||||
| RefSeq (protein) | NP_002407.1 | NP_032625.2 | |||||||||||
| Location (UCSC) | Chr 4: 76.92 – 76.93 Mb |
Chr 5: 92.75 – 92.76 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4.[1][2] CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.[3]
Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.
Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.
CXCL9 has been shown to interact with CXCR3.[4][5]
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