CXCL5

Chemokine (C-X-C motif) ligand 5

Identifiers

CXCL5; ENA-78; SCYB5

External IDs

OMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5 Gene

Gene Ontology
Molecular function	• chemokine activity
Cellular component	• extracellular region • extracellular region • extracellular space
Biological process	• chemotaxis • immune response • signal transduction • cell-cell signaling • positive regulation of cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_002994.3

n/a

RefSeq (protein)

NP_002985.1

n/a

Location (UCSC)

Chr 4:
74.86 – 74.86 Mb

n/a

PubMed search

[1]

n/a

C-X-C motif chemokine 5 or ENA-78 is a protein that in humans is encoded by the CXCL5 gene.^[1]^[2]

1 Function
2 Clinical significance
3 References
4 Further reading

Function

The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha.^[3] Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ.^[4] This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.^[4] The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes.^[3]^[5] CXCL5 has been implicated in connective tissue remodelling.^[4]

Clinical significance

CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a "potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis."^[6]

References

^ Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J Biol Chem 269 (41): 25277–82. PMID 7929219.
^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6374.
^ ^a ^b Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. PMID 7929219. http://www.jbc.org/cgi/content/abstract/269/41/25277.
^ ^a ^b ^c Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils". Clin. Exp. Allergy 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872.
^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098.
^ Dawes JM, Calvo M, Perkins JR, Paterson KJ, Kiesewetter H, Hobbs C, Kaan TK, Orengo C, Bennett DL, McMahon SB (July 2011). "CXCL5 Mediates UVB Irradiation-Induced Pain". Sci Transl Med 3 (90): 90ra60. doi:10.1126/scitranslmed.3002193. PMID 21734176. Lay summary – FierceBiotech.

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5". J. Immunol. 179 (7): 4849–56. PMID 17878384.
Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease". J. Leukoc. Biol. 62 (5): 604–11. PMID 9365115.
Struyf S, Proost P, Van Damme J (2004). "Regulation of the immune response by the interaction of chemokines and proteases". Adv. Immunol.. Advances in Immunology 81: 1–44. doi:10.1016/S0065-2776(03)81001-5. ISBN 978-0-12-022481-4. PMID 14711052.
Walz A, Burgener R, Car B, et al. (1992). "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8". J. Exp. Med. 174 (6): 1355–62. doi:10.1084/jem.174.6.1355. PMC 2119025. PMID 1744577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119025.
Power CA, Furness RB, Brawand C, Wells TN (1995). "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets". Gene 151 (1–2): 333–4. doi:10.1016/0378-1119(94)90682-3. PMID 7828901.
Corbett MS, Schmitt I, Riess O, Walz A (1995). "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)". Biochem. Biophys. Res. Commun. 205 (1): 612–7. doi:10.1006/bbrc.1994.2709. PMID 7999089.
Koch AE, Kunkel SL, Harlow LA, et al. (1994). "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis". J. Clin. Invest. 94 (3): 1012–8. doi:10.1172/JCI117414. PMC 295150. PMID 8083342. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=295150.
Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". Cytokine 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.
Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
Keates S, Keates AC, Mizoguchi E, et al. (1997). "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis". Am. J. Physiol. 273 (1 Pt 1): G75–82. PMID 9252512.
Wuyts A, Proost P, Lenaerts JP, et al. (1998). "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78". Eur. J. Biochem. 255 (1): 67–73. doi:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902.
Wyrick PB, Knight ST, Paul TR, et al. (1999). "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis". J. Infect. Dis. 179 (4): 954–66. doi:10.1086/314676. PMID 10068592.
Wuyts A, Govaerts C, Struyf S, et al. (1999). "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms". Eur. J. Biochem. 260 (2): 421–9. doi:10.1046/j.1432-1327.1999.00166.x. PMID 10095777.
Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines". FASEB J. 13 (12): 1565–74. PMID 10463948.
Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. PMID 10820279.
Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). "Control of chemokine production at the blood–retina barrier". Immunology 101 (3): 426–33. doi:10.1046/j.0019-2805.2000.01105.x. PMC 2327097. PMID 11106948. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2327097.
Zhang C, Thornton MA, Kowalska MA, et al. (2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus". Blood 98 (3): 610–7. doi:10.1182/blood.V98.3.610. PMID 11468158.
Chandrasekar B, Melby PC, Sarau HM, et al. (2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway". J. Biol. Chem. 278 (7): 4675–86. doi:10.1074/jbc.M207006200. PMID 12468547.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

Cell signaling: cytokines

By family

Chemokine

CCL	CCL1 · CCL2/MCP-1 · CCL3/MIP-1α · CCL4/MIP-1β · CCL5/RANTES · CCL6 · CCL7 · CCL8 · CCL9 · CCL11 · CCL12 · CCL13 · CCL14 · CCL15 · CCL16 · CCL17 · CCL18 · CCL19 · CCL20 · CCL21 · CCL22 · CCL23 · CCL24 · CCL25 · CCL26 · CCL27 · CCL28

CXCL	CXCL1/KC · CXCL2 · CXCL3 · CXCL4 · CXCL5 · CXCL6 · CXCL7 · CXCL8/IL8 · CXCL9 · CXCL10 · CXCL11 · CXCL12 · CXCL13 · CXCL14 · CXCL15 · CXCL16 · CXCL17

CX3CL	CX3CL1

XCL	XCL1 · XCL2

TNF

TNFA · Lymphotoxin (TNFB/LTA, TNFC/LTB) · TNFSF4 · TNFSF5/CD40LG · TNFSF6 · TNFSF7 · TNFSF8 · TNFSF9 · TNFSF10 · TNFSF11 · TNFSF13B · EDA

Interleukin

Type I
(grouped by
receptor
subunit)

γ-chain	IL2/IL15 · IL4/IL13 · IL7 · IL9 · IL21

β-chain	IL3 · IL5 · GM-CSF

IL6 like/gp130	IL6 · IL11 · IL27 · IL30 · IL31 (+non IL OSM, LIF, CNTF, CTF1)

IL-12 family/IL12RB1	IL12 · IL23 · IL27 · IL35

Other	IL14 · IL16 · IL32 · IL34

Type II

IL-10 family

IL10/IL22 · IL19 · IL20 · IL24 · IL26 · Interferon type III (IL28/IFNL2+3 · IL29/IFNL1)

Interferon

I	IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNK, IFNW1

II	IFNG

Ig superfamily

IL-1 family: IL1A/IL1F1 · IL1B/IL1F2 · 1Ra/IL1F3 · IL1F5 · IL1F6 · IL1F7 · IL1F8 · IL1F9 · IL1F10 · 33/IL1F11 · 18/IL1G

IL-17 family

IL17/IL25 (IL17A)

Other

Hematopoietic (KITLG, Colony-stimulating factor) · SPP1

By function/
cell

proinflammatory cytokine (IL1, TNFA)

Monokine · Lymphokine (T_h1 (IFNG and TNFB) · T_h2 (IL4, IL5, IL6, IL10, IL13) )

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

CXCL5

Contents

Function

Clinical significance

References

Further reading