CUL7

Cullin 7

PDB rendering based on 2jng.

Available structures
PDB	2jng

Identifiers

Symbols

CUL7; KIAA0076; dJ20C7.5

External IDs

OMIM: 609577 MGI: 1913765 HomoloGene: 56683 GeneCards: CUL7 Gene

Gene Ontology
Molecular function	• protein binding • ubiquitin protein ligase binding
Cellular component	• nucleus • anaphase-promoting complex • cytoplasm • mitochondrion
Biological process	• vasculogenesis • proteolysis • ubiquitin-dependent protein catabolic process • interspecies interaction between organisms
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
43.01 – 43.02 Mb

Chr 17:
46.79 – 46.8 Mb

PubMed search

[1]

[2]

Cullin-7 is a protein that in humans is encoded by the CUL7 gene.^[1]^[2]^[3]

1 Clinical significance
2 Interactions
3 References
4 Further reading
5 External Links

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.^[1]

References

^ ^a ^b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139190.
^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187864.
^ "Entrez Gene: CUL7 cullin 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9820.

Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene.". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function.". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2040908.
Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes.". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7.". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.". Oncogene 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496.
Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome.". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

External Links

PDB gallery

2jng: Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.

Cell cycle proteins

Cyclin

A (A1, A2) · B (B1, B2, B3) · D (D1, D2, D3) · E (E1, E2)

CDK

2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · CDK-activating kinase

CDK inhibitor

INK4a/ARF (p14arf/p16, p15, p18, p19) · cip/kip (p21, p27, p57)

P53 p63 p73 family

p53 · p63 · p73

Phases and
checkpoints

Interphase	G₁ phase · S phase · G₂ phase

M phase	Mitosis (Preprophase · Prophase · Prometaphase · Metaphase · Anaphase · Telophase) · Cytokinesis

Cell cycle checkpoints	Restriction point · Spindle checkpoint · Postreplication checkpoint

Other cellular phases	Apoptosis · G₀ phase · Meiosis

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

CUL7

Contents

Clinical significance

Interactions

References

Further reading

External Links