Catenin (cadherin-associated protein), alpha 1
Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene.[1][2]
Interactions
Catenin (cadherin-associated protein), alpha 1 has been shown to interact with Beta-catenin,[3][4][5][6][7] Plakoglobin,[4][8][9] VE-cadherin,[10][11] CDH1,[12][13][14][15][16] CDH2,[17][18] CDH3[16][19] and APC.[20][21]
See also
References
- ^ Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Nov 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156–60. doi:10.1073/pnas.88.20.9156. PMC 52671. PMID 1924379. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52671.
- ^ "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1495.
- ^ Oyama, T; Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F (Dec. 1994). "A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. (UNITED STATES) 54 (23): 6282–7. ISSN 0008-5472. PMID 7954478.
- ^ a b Roe, S; Koslov E R, Rimm D L (Jun. 1998). "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity". Cell Adhes. Commun. (SWITZERLAND) 5 (4): 283–96. doi:10.3109/15419069809040298. ISSN 1061-5385. PMID 9762469.
- ^ Piedra, Jose; Miravet Susana, Castaño Julio, Pálmer Héctor G, Heisterkamp Nora, García de Herreros Antonio, Duñach Mireia (Apr. 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. (United States) 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150740.
- ^ Aberle, H; Butz S, Stappert J, Weissig H, Kemler R, Hoschuetzky H (Dec. 1994). "Assembly of the cadherin-catenin complex in vitro with recombinant proteins". J. Cell. Sci. (ENGLAND) 107 ( Pt 12): 3655–63. ISSN 0021-9533. PMID 7706414.
- ^ Reuver, S M; Garner C C (Apr. 1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton". J. Cell. Sci. (ENGLAND) 111 ( Pt 8): 1071–80. ISSN 0021-9533. PMID 9512503.
- ^ Sacco, P A; McGranahan T M, Wheelock M J, Johnson K R (Aug. 1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin". J. Biol. Chem. (UNITED STATES) 270 (34): 20201–6. doi:10.1074/jbc.270.34.20201. ISSN 0021-9258. PMID 7650039.
- ^ Obama, H; Ozawa M (Apr. 1997). "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J. Biol. Chem. (UNITED STATES) 272 (17): 11017–20. doi:10.1074/jbc.272.17.11017. ISSN 0021-9258. PMID 9110993.
- ^ Lewalle, J M; Bajou K, Desreux J, Mareel M, Dejana E, Noël A, Foidart J M (Dec. 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro". Exp. Cell Res. (UNITED STATES) 237 (2): 347–56. doi:10.1006/excr.1997.3799. ISSN 0014-4827. PMID 9434630.
- ^ Shasby, D Michael; Ries Dana R, Shasby Sandra S, Winter Michael C (Jun. 2002). "Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin". Am. J. Physiol. Lung Cell Mol. Physiol. (United States) 282 (6): L1330–8. doi:10.1152/ajplung.00329.2001. ISSN 1040-0605. PMID 12003790.
- ^ Kinch, M S; Clark G J, Der C J, Burridge K (Jul. 1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. (UNITED STATES) 130 (2): 461–71. doi:10.1083/jcb.130.2.461. ISSN 0021-9525. PMC 2199929. PMID 7542250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199929.
- ^ Oneyama, Chitose; Nakano Hirofumi, Sharma Sreenath V (Mar. 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug". Oncogene (England) 21 (13): 2037–50. doi:10.1038/sj.onc.1205271. ISSN 0950-9232. PMID 11960376.
- ^ Navarro, P; Lozano E, Cano A (Aug. 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". J. Cell. Sci. (ENGLAND) 105 ( Pt 4): 923–34. ISSN 0021-9533. PMID 8227214.
- ^ Takahashi, K; Suzuki K, Tsukatani Y (Jul. 1997). "Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence". Oncogene (ENGLAND) 15 (1): 71–8. doi:10.1038/sj.onc.1201160. ISSN 0950-9232. PMID 9233779.
- ^ a b Schmeiser, K; Grand R J (Apr. 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death Differ. (ENGLAND) 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. ISSN 1350-9047. PMID 10381631.
- ^ Straub, Beate K; Boda Judit, Kuhn Caecilia, Schnoelzer Martina, Korf Ulrike, Kempf Tore, Spring Herbert, Hatzfeld Mechthild, Franke Werner W (Dec. 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392.
- ^ Wahl, James K; Kim Young J, Cullen Janet M, Johnson Keith R, Wheelock Margaret J (May. 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. (United States) 278 (19): 17269–76. doi:10.1074/jbc.M211452200. ISSN 0021-9258. PMID 12604612.
- ^ Klingelhöfer, J; Troyanovsky R B, Laur O Y, Troyanovsky S (Aug. 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci. (ENGLAND) 113 ( Pt 16): 2829–36. ISSN 0021-9533. PMID 10910767.
- ^ Su, L K; Vogelstein B, Kinzler K W (Dec. 1993). "Association of the APC tumor suppressor protein with catenins". Science (UNITED STATES) 262 (5140): 1734–7. doi:10.1126/science.8259519. ISSN 0036-8075. PMID 8259519.
- ^ Daniel, J M; Reynolds A B (Sep. 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4819–24. ISSN 0270-7306. PMC 230726. PMID 7651399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230726.
Further reading
- Nagafuchi A, Takeichi M, Tsukita S (1991). "The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.". Cell 65 (5): 849–57. doi:10.1016/0092-8674(91)90392-C. PMID 1904011.
- Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199929.
- Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.". J. Biol. Chem. 270 (34): 20201–6. doi:10.1074/jbc.270.34.20201. PMID 7650039.
- Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin.". Mol. Cell. Biol. 15 (9): 4819–24. PMC 230726. PMID 7651399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230726.
- Aberle H, Butz S, Stappert J, et al. (1995). "Assembly of the cadherin-catenin complex in vitro with recombinant proteins.". J. Cell. Sci. 107 ( Pt 12): 3655–63. PMID 7706414.
- Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (1995). "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.". J. Cell Biol. 130 (1): 67–77. doi:10.1083/jcb.130.1.67. PMC 2120515. PMID 7790378. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120515.
- Rimm DL, Kebriaei P, Morrow JS (1994). "Molecular cloning reveals alternative splice forms of human alpha(E)-catenin.". Biochem. Biophys. Res. Commun. 203 (3): 1691–9. doi:10.1006/bbrc.1994.2381. PMID 7945318.
- Oyama T, Kanai Y, Ochiai A, et al. (1994). "A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.". Cancer Res. 54 (23): 6282–7. PMID 7954478.
- McPherson JD, Morton RA, Ewing CM, et al. (1994). "Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22.". Genomics 19 (1): 188–90. doi:10.1006/geno.1994.1042. PMID 8188230.
- Su LK, Vogelstein B, Kinzler KW (1994). "Association of the APC tumor suppressor protein with catenins.". Science 262 (5140): 1734–7. doi:10.1126/science.8259519. PMID 8259519.
- Oda T, Kanai Y, Shimoyama Y, et al. (1993). "Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.". Biochem. Biophys. Res. Commun. 193 (3): 897–904. doi:10.1006/bbrc.1993.1710. PMID 8323564.
- Furukawa Y, Nakatsuru S, Nagafuchi A, et al. (1993). "Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1).". Cytogenet. Cell Genet. 65 (1-2): 74–8. doi:10.1159/000133603. PMID 8404069.
- Obama H, Ozawa M (1997). "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin).". J. Biol. Chem. 272 (17): 11017–20. doi:10.1074/jbc.272.17.11017. PMID 9110993.
- Linkels M, Bussemakers MJ, Nollet F, et al. (1997). "Molecular cloning of an alternative human alphaE-catenin cDNA.". Biochem. Biophys. Res. Commun. 237 (1): 177–81. doi:10.1006/bbrc.1997.7058. PMID 9266853.
- Lewalle JM, Bajou K, Desreux J, et al. (1998). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro.". Exp. Cell Res. 237 (2): 347–56. doi:10.1006/excr.1997.3799. PMID 9434630.
- Reuver SM, Garner CC (1998). "E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.". J. Cell. Sci. 111 ( Pt 8): 1071–80. PMID 9512503.
- Watabe-Uchida M, Uchida N, Imamura Y, et al. (1998). "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.". J. Cell Biol. 142 (3): 847–57. doi:10.1083/jcb.142.3.847. PMC 2148175. PMID 9700171. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2148175.
- Roe S, Koslov ER, Rimm DL (1998). "A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity.". Cell Adhes. Commun. 5 (4): 283–96. doi:10.3109/15419069809040298. PMID 9762469.
- Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.". J. Biol. Chem. 274 (9): 5981–6. doi:10.1074/jbc.274.9.5981. PMID 10026224.
PDB gallery
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1dov: CRYSTAL STRUCTURE OF THE ALPHA-CATENIN DIMERIZATION DOMAIN
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1dow: CRYSTAL STRUCTURE OF A CHIMERA OF BETA-CATENIN AND ALPHA-CATENIN
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1h6g: ALPHA-CATENIN M-DOMAIN
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1l7c: alpha-catenin fragment, residues 385-651
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