CTBP2

C-terminal binding protein 2

PDB rendering based on 2ome.
Identifiers
Symbols CTBP2;
External IDs OMIM: 602619 MGI: 1201686 HomoloGene: 75187 GeneCards: CTBP2 Gene
Orthologs
Species Human Mouse
Entrez 1488 13017
Ensembl ENSG00000175029 ENSMUSG00000030970
UniProt P56545 Q3UGL5
RefSeq (mRNA) NM_001083914.1 NM_009980
RefSeq (protein) NP_001077383.1 NP_034110
Location (UCSC) Chr 10:
126.68 – 126.85 Mb		 Chr 7:
140.18 – 140.32 Mb
PubMed search [1] [2]

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.[1][2][3]

Contents

Function

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor (corepressor), while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.[3]

Interactions

CTBP2 has been shown to interact with FHL3,[4] SOX6,[5] KLF3,[4][6] NRIP1,[7][8] ZFPM2,[9] Mdm2[10] and KLF8.[11]

References

  1. ^ Katsanis N, Fisher EM (Apr 1998). "A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3". Genomics 47 (2): 294–9. doi:10.1006/geno.1997.5115. PMID 9479502. 
  2. ^ Chinnadurai G (Feb 2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol Cell 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595. 
  3. ^ a b "Entrez Gene: CTBP2 C-terminal binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1488. 
  4. ^ a b Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451. 
  5. ^ Murakami, A; Ishida S, Thurlow J, Revest J M, Dickson C (Aug. 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. (England) 29 (16): 3347–55. doi:10.1093/nar/29.16.3347. PMC 55854. PMID 11504872. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55854. 
  6. ^ Turner, J; Crossley M (Sep. 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. (ENGLAND) 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. ISSN 0261-4189. PMC 1170841. PMID 9724649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170841. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Castet, Audrey; Boulahtouf Abdelhay, Versini Gwennaëlle, Bonnet Sandrine, Augereau Patrick, Vignon Françoise, Khochbin Saadi, Jalaguier Stéphan, Cavaillès Vincent (2004). "Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition". Nucleic Acids Res. (England) 32 (6): 1957–66. doi:10.1093/nar/gkh524. PMC 390375. PMID 15060175. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=390375. 
  9. ^ Holmes, M; Turner J, Fox A, Chisholm O, Crossley M, Chong B (Aug. 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. (UNITED STATES) 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. ISSN 0021-9258. PMID 10438528. 
  10. ^ Mirnezami, Alexander H; Campbell Sandra J, Darley Matthew, Primrose John N, Johnson Peter W M, Blaydes Jeremy P (Jul. 2003). "Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription". Curr. Biol. (England) 13 (14): 1234–9. doi:10.1016/S0960-9822(03)00454-8. ISSN 0960-9822. PMID 12867035. 
  11. ^ van Vliet, J; Turner J, Crossley M (May. 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Res. (ENGLAND) 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=103308. 

Further reading

External links

Coactivators
ARA (54, 55, 70) • BCAS3 • CARM1 • p300-CBP (EP300, CREBBP) • CRTC (1, 2, 3) • DRIP/TRAP • MN1 • PCAF • PNRC (1, 2) • PPARGC (1A, 1B) • TGFB1I1
NCOA1 (SRC-1) • NCOA2 (GRIP1/SRC-2/TIF2) • NCOA3 (AIB/SRC-3/TRAM-1) • NCOA4 (ARA70) • NCOA5 (CIA) • NCOA6 (RAP250) • NCOA7 (ERAP140)
Corepressors
CTBP (1, 2) • Hairless homolog • LCOR • NRIP1 (RIP140) • PELP-1 • RCOR1 • Rb • SIN3A • SIN3B • Tripartite motif family TRIM (24, 28, 33)
NCOR1 • NCOR2 (SMRT)
ATP-dependent remodeling factors
see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)