CRTC2

CREB regulated transcription coactivator 2
Identifiers
Symbols CRTC2; TORC-2; TORC2
External IDs OMIM: 608972 MGI: 1921593 HomoloGene: 18765 GeneCards: CRTC2 Gene
Orthologs
Species Human Mouse
Entrez 200186 74343
Ensembl ENSG00000160741 ENSMUSG00000027936
UniProt Q53ET0 n/a
RefSeq (mRNA) NM_181715 NM_028881.2
RefSeq (protein) NP_859066 NP_083157.1
Location (UCSC) Chr 1:
153.92 – 153.93 Mb		 Chr 3:
90.06 – 90.07 Mb
PubMed search [1] [2]

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[1][2][3]

Contents

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[4]

Interactions

CRTC2 has been shown to interact with SNF1LK2[5] and YWHAQ.[5][6]

References

  1. ^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186. 
  2. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=218727. 
  3. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  4. ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". Bioessays 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585. 
  5. ^ a b Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct. 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell (United States) 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. ISSN 0092-8674. PMID 15454081. 
  6. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

Further reading

External links

Coactivators
ARA (54, 55, 70) • BCAS3 • CARM1 • p300-CBP (EP300, CREBBP) • CRTC (1, 2, 3) • DRIP/TRAP • MN1 • PCAF • PNRC (1, 2) • PPARGC (1A, 1B) • TGFB1I1
NCOA1 (SRC-1) • NCOA2 (GRIP1/SRC-2/TIF2) • NCOA3 (AIB/SRC-3/TRAM-1) • NCOA4 (ARA70) • NCOA5 (CIA) • NCOA6 (RAP250) • NCOA7 (ERAP140)
Corepressors
CTBP (1, 2) • Hairless homolog • LCOR • NRIP1 (RIP140) • PELP-1 • RCOR1 • Rb • SIN3A • SIN3B • Tripartite motif family TRIM (24, 28, 33)
NCOR1 • NCOR2 (SMRT)
ATP-dependent remodeling factors
see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)