CRMP1

Collapsin response mediator protein 1

PDB rendering based on 1kcx.

Available structures
PDB	1kcx

Identifiers

Symbols

CRMP1; CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3

External IDs

OMIM: 602462 MGI: 107793 HomoloGene: 20347 GeneCards: CRMP1 Gene

Gene Ontology
Molecular function	• dihydropyrimidinase activity • protein binding
Cellular component	• cytoplasm • microtubule organizing center • spindle • cytosol • cytoskeleton
Biological process	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • pyrimidine base catabolic process • nervous system development • axon guidance
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
5.75 – 5.89 Mb

Chr 5:
37.63 – 37.68 Mb

PubMed search

[1]

[2]

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.^[1]

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.^[1]

CRMP1 mediates reelin signaling in cortical neuronal migration.^[2] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.^[3]

CRMP1 gene overlaps with another gene called EVC.^[4]

Interactions

CRMP1 has been shown to interact with DPYSL2.^[5]

References

^ ^a ^b "Entrez Gene: CRMP1 collapsin response mediator protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1400.
^ Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y (December 2006). "Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration". J. Neurosci. 26 (51): 13357–62. doi:10.1523/JNEUROSCI.4276-06.2006. PMID 17182786. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17182786.
^ Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW (March 2007). "Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory". J. Neurosci. 27 (10): 2513–24. doi:10.1523/JNEUROSCI.4497-06.2007. PMID 17344389. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17344389.
^ Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J (March 2000). "Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis". Nat. Genet. 24 (3): 283–6. doi:10.1038/73508. PMID 10700184.
^ Leung, Thomas; Ng Yvonne, Cheong Albert, Ng Chong Han, Tan Ivan, Hall Christine, Lim Louis (Dec. 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. (Netherlands) 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.

Shih JY, Lee YC, Yang SC, et al. (2003). "Collapsin response mediator protein-1: a novel invasion-suppressor gene". Clin. Exp. Metastasis 20 (1): 69–76. doi:10.1023/A:1022598604565. PMID 12650609.
Hamajima N, Matsuda K, Sakata S, et al. (1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
Torres R, Polymeropoulos MH (1999). "Genomic organization and localization of the human CRMP-1 gene". DNA Res. 5 (6): 393–5. doi:10.1093/dnares/5.6.393. PMID 10048489.
Shih JY, Yang SC, Hong TM, et al. (2001). "Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells". J. Natl. Cancer Inst. 93 (18): 1392–400. doi:10.1093/jnci/93.18.1392. PMID 11562390.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chang CC, Shih JY, Jeng YM, et al. (2004). "Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis". J. Natl. Cancer Inst. 96 (5): 364–75. doi:10.1093/jnci/djh059. PMID 14996858.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Sivakumaran TA, Lesperance MM (2005). "Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes". Int. J. Mol. Med. 14 (5): 903–7. PMID 15492864.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Cole AR, Causeret F, Yadirgi G, et al. (2006). "Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc.M513344200. PMC 1805471. PMID 16611631. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1805471.
Weidemann W, Stelzl U, Lisewski U, et al. (2007). "The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis". FEBS Lett. 580 (28–29): 6649–54. doi:10.1016/j.febslet.2006.11.015. PMID 17118363.

PDB gallery

1kcx: X-ray structure of NYSGRC target T-45

CRMP1

Interactions

References

Further reading