CRLF3

Cytokine receptor-like factor 3

Identifiers

CRLF3; CREME9; CYTOR4; FRWS; MGC20661; p48.2

External IDs

HomoloGene: 9327 GeneCards: CRLF3 Gene

Gene Ontology
Cellular component	• cytoplasm
Biological process	• negative regulation of cell growth • negative regulation of S phase of mitotic cell cycle • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JAK-STAT cascade • positive regulation of cell cycle arrest
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000176390

ENSMUSG00000017561

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
29.11 – 29.15 Mb

Chr 11:
79.86 – 79.89 Mb

PubMed search

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.^[1]

References

^ "Entrez Gene: cytokine receptor-like factor 3". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=51379.

Further reading

Visser R, Koelma N, Vijfhuizen L, et al. (2009). "RNF135 mutations are not present in patients with Sotos syndrome-like features.". Am. J. Med. Genet. A 149A (4): 806–8. doi:10.1002/ajmg.a.32694. PMID 19291764.
Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height.". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
Zhao J, Li M, Bradfield JP, et al. (2010). "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.". BMC Med. Genet. 11: 96. doi:10.1186/1471-2350-11-96. PMID 20546612.
Yang F, Xu YP, Li J, et al. (2009). "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.". Int. J. Biochem. Cell Biol. 41 (11): 2240–50. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
Gevaert K, Goethals M, Martens L, et al. (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Johnatty SE, Beesley J, Chen X, et al. (2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".". PLoS Genet. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMID 20628624.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome.". Mol. Cell Proteomics 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510.