COPZ1

Coatomer protein complex, subunit zeta 1

Identifiers

COPZ1; COPZ; zeta1-COP

External IDs

MGI: 1929063 HomoloGene: 9366 GeneCards: COPZ1 Gene

Gene Ontology
Cellular component	• Golgi membrane • cytoplasm • Golgi apparatus • cytosol • cytosol • membrane • membrane coat • COPI vesicle coat • COPI vesicle coat • cytoplasmic vesicle
Biological process	• intracellular protein transport • retrograde vesicle-mediated transport, Golgi to ER • retrograde vesicle-mediated transport, Golgi to ER • intra-Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • cellular membrane organization • vesicle-mediated transport • COPI coating of Golgi vesicle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
54.72 – 54.75 Mb

Chr 15:
103.1 – 103.13 Mb

PubMed search

[1]

[2]

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.^[1]

Interactions

COPZ1 has been shown to interact with COPG.^[2]^[3]

References

^ "Entrez Gene: COPZ1 coatomer protein complex, subunit zeta 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22818.
^ Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (November 2000). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. PMID 11056392.
^ Faulstich, D; Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland F T, Tschochner H (Oct. 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. (UNITED STATES) 135 (1): 53–61. doi:10.1083/jcb.135.1.53. ISSN 0021-9525. PMC 2121028. PMID 8858162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2121028.

Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell 102 (6): 713–9. doi:10.1016/S0092-8674(00)00060-X. PMID 11030615.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19276.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Futatsumori M, Kasai K, Takatsu H, et al. (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. PMID 11056392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 · SNAP29 Syntaxin (STX1A, STX1B, STX2, STX3, STX4, STX5, STX6, STX7, STX8, STX10, STX11, STX12, STX16, STX17, STX18, STX19) Munc-18: STXBP1 · STXBP2 · STXBP3 · STXBP4 · STXBP5 · STXBP6

R-SNARE	Synaptobrevin/VAMP: VAMP1 · VAMP2 · VAMP3

Synaptotagmin

SYT1 · SYT2 · SYT3 · SYT4 · SYT5 · SYT6 · SYT7 · SYT8 · SYT9 · SYT10 · SYT11 · SYT12 · SYT13 · SYT14 · SYT15 · SYT16 · SYT17

Other

Synaptophysin · Synapsin

Small GTPase: RAB3A

COPI

Coatomer (COPA, COPB1, COPB2, COPE, COPG, COPG2, COPZ1, COPZ2)

Archain

Small GTPase: ARF

COPII

Vesicle formation: SEC23A

Small GTPase: SAR1A

RME/Clathrin

CLTA · CLTB · CLTC

Caveolae

Caveolin (CAV1 · CAV2 · CAV3)

Other/ungrouped

Vesicle formation	Adaptor protein complex 1: AP1AR · AP1B1 · AP1G1 · AP1G2 · AP1M1 · AP1M2 · AP1S1 · AP1S2 · AP1S3 Adaptor protein complex 2: AP2A1 · AP2A2 · AP2B1 · AP2M1 · AP2S1 Adaptor protein complex 3: AP3B1 · AP3B2 · AP3D1 · AP3M1 · AP3M2 · AP3S1 · AP3S2 Adaptor protein complex 4: AP4B1 · AP4E1 · AP4M1 · AP4S1 LMAN1 LYST BLOC-1: DTNBP1 · BLOC153 BLOC-2: HPS3 · HPS5 · HPS6 BLOC-3: HPS1 · HPS4 Coats: Retromer · TIP47

Small GTPase	Dynamin (DNM1, DNM2, DNM3)

Other	EHD protein family: EHD1 · EHD2 · EHD3 · EHD4 Sorting nexins vacuolar protein sorting: VPS13B · VPS33B SYNRG

see also vesicular transport protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

COPZ1

Interactions

References

Further reading