COPS2

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

Identifiers

COPS2; ALIEN; CSN2; SGN2; TRIP15

External IDs

OMIM: 604508 MGI: 1330276 HomoloGene: 3124 GeneCards: COPS2 Gene

Gene Ontology
Molecular function	• signal transducer activity • protein binding
Cellular component	• nucleus • nucleolus • cytoplasm • signalosome • intracellular membrane-bounded organelle
Biological process	• transcription from RNA polymerase II promoter • signal transduction • cullin deneddylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
49.42 – 49.45 Mb

Chr 2:
125.66 – 125.68 Mb

PubMed search

[1]

[2]

COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.^[1]^[2]^[3]

Interactions

COPS2 has been shown to interact with IRF8,^[4] NIF3L1,^[5] Thyroid hormone receptor alpha^[6] and DAX1.^[7]

References

^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J 12 (6): 469–78. PMID 9535219.
^ "Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9318.
^ Cohen, H; Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, Kraft R, Dubiel W, Levi B Z (Dec. 2000). "Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. (UNITED STATES) 275 (50): 39081–9. doi:10.1074/jbc.M004900200. ISSN 0021-9258. PMID 10991940.
^ Akiyama, Hirotada; Fujisawa Naoko, Tashiro Yousuke, Takanabe Natsuko, Sugiyama Akinori, Tashiro Fumio (Mar. 2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. (United States) 278 (12): 10752–62. doi:10.1074/jbc.M209856200. ISSN 0021-9258. PMID 12522100.
^ Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (May. 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383–94. ISSN 0270-7306. PMC 84131. PMID 10207062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84131.
^ Altincicek, B; Tenbaum S P, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A (Mar. 2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. (UNITED STATES) 275 (11): 7662–7. doi:10.1074/jbc.275.11.7662. ISSN 0021-9258. PMID 10713076.

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
Schaefer L, Beermann ML, Miller JB (1999). "Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien". Genomics 56 (3): 310–6. doi:10.1006/geno.1998.5728. PMID 10087198.
Dressel U, Thormeyer D, Altincicek B, et al. (1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 84131. PMID 10207062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84131.
Naumann M, Bech-Otschir D, Huang X, et al. (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK". J. Biol. Chem. 274 (50): 35297–300. doi:10.1074/jbc.274.50.35297. PMID 10585392.
Altincicek B, Tenbaum SP, Dressel U, et al. (2000). "Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita". J. Biol. Chem. 275 (11): 7662–7. doi:10.1074/jbc.275.11.7662. PMID 10713076.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Cohen H, Azriel A, Cohen T, et al. (2001). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi:10.1074/jbc.M004900200. PMID 10991940.
Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145508.
Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Akiyama H, Fujisawa N, Tashiro Y, et al. (2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". J. Biol. Chem. 278 (12): 10752–62. doi:10.1074/jbc.M209856200. PMID 12522100.
Serino G, Su H, Peng Z, et al. (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex". Plant Cell 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150025.
Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151059.

COPS2

Interactions

References

Further reading