Collagen, type XVI, alpha 1
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.[1][2]
This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.[2]
References
Further reading
- Yamaguchi N, Kimura S, McBride OW, et al. (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.". J. Biochem. 112 (6): 856–63. PMID 1284248.
- Sires UI, Dublet B, Aubert-Foucher E, et al. (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase.". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
- Tillet E, Mann K, Nischt R, et al. (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain.". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
- Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells.". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kassner A, Hansen U, Miosge N, et al. (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
- Kassner A, Tiedemann K, Notbohm H, et al. (2004). "Molecular structure and interaction of recombinant human type XVI collagen.". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Eble JA, Kassner A, Niland S, et al. (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.
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| Extracellular matrix |
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Fibril forming
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Other
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FACIT: type IX (COL9A1, COL9A2, COL9A3) · type XII (COL12A1) · COL14A1 · COL16A1 · COL19A1 · COL20A1 · COL21A1 · COL22A1
basement membrane: type IV (COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6)
multiplexin: COL15A1 · type XVIII (COL18A1, Endostatin)
transmembrane: COL13A1 · COL17A1 · COL23A1 · COL25A1
other: type VI ( COL6A1, COL6A2, COL6A3) · type VII ( COL7A1) · type VIII ( COL8A1, COL8A2) · type X ( COL10A1) · type XI ( COL11A1, COL11A2) · COL27A1 · COL28A1 · COL29A1
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Other
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see also diseases
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous
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