Ciliary neurotrophic factor receptor

ciliary neurotrophic factor receptor
Identifiers
Symbol CNTFR
Entrez 1271
HUGO 2170
OMIM 118946
RefSeq NM_001842
UniProt P26992
Other data
Locus Chr. 9 p13

The ciliary neurotrophic factor receptor also known as CNTFR binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]

Model organisms

Model organisms have been used in the study of CNTFR function. A conditional knockout mouse line, called Cntfrtm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: no homozygous mutant animals were observed at weaning. The remaining tests were therefore carried out on adult heterozygous mutant animals, but no further abnormalities were seen. [5]

References

  1. ^ Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary neurotrophic factor". Science 253 (5015): 59–63. doi:10.1126/science.1648265. PMID 1648265. 
  2. ^ Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv 74 (2–3): 265–72. doi:10.1016/S0031-6865(99)00050-3. PMID 10812968. 
  3. ^ "Salmonella infection data for Cntfr". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MBFZ/salmonella-challenge/. 
  4. ^ "Citrobacter infection data for Cntfr". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MBFZ/citrobacter-challenge/. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Cntfr. 
  8. ^ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4433013. 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474: 262-263. doi:10.1038/474262a. http://www.nature.com/news/2011/110615/full/474262a.html. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). A mouse for all reasons. Cell 128(1): 9-13. doi:10.1016/j.cell.2006.12.018 PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMID 21722353. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21722353. 

External links

Type I cytokine receptor

Nerve growth factors: Ciliary neurotrophic factor

Erythropoietin
Receptor protein serine/threonine kinase
Receptor tyrosine kinase
Tumor necrosis factor receptor
Ig superfamily
Other/ungrouped
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)