Cyclic nucleotide-gated channel alpha 1

Cyclic nucleotide gated channel alpha 1

Identifiers

CNGA1; CNCG; CNCG1; CNG1; RCNC1; RCNCa; RCNCalpha; RP49

External IDs

OMIM: 123825 MGI: 88436 HomoloGene: 55432 IUPHAR: CNGA1 GeneCards: CNGA1 Gene

Gene Ontology
Molecular function	• nucleotide binding • ion channel activity • cGMP binding
Cellular component	• cytoplasm • integral to plasma membrane • membrane • intracellular cyclic nucleotide activated cation channel complex
Biological process	• transport • ion transport • spermatogenesis • visual perception • response to stimulus • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
47.94 – 48.02 Mb

Chr 5:
72.99 – 73.03 Mb

PubMed search

[1]

[2]

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.^[1]

1 See also
2 References
3 Further reading
4 External links

References

^ "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1259.

Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
Pittler SJ, Lee AK, Altherr MR, et al. (1992). "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel.". J. Biol. Chem. 267 (9): 6257–62. PMID 1372902.
Arsenault TV, Sauder DN, Harley CB, McKenzie RC (1992). "Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes.". Mol. Immunol. 29 (3): 431–8. doi:10.1016/0161-5890(92)90031-R. PMID 1372959.
Dhallan RS, Macke JP, Eddy RL, et al. (1992). "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.". J. Neurosci. 12 (8): 3248–56. PMID 1379636.
Dryja TP, Finn JT, Peng YW, et al. (1995). "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10177–81. doi:10.1073/pnas.92.22.10177. PMC 40759. PMID 7479749. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40759.
Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.". Neuropharmacology 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814.
Griffin CA, Ding CL, Jabs EW, et al. (1993). "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization.". Genomics 16 (1): 302–3. doi:10.1006/geno.1993.1187. PMID 7683629.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Paloma E, Martínez-Mir A, García-Sandoval B, et al. (2002). "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa.". J. Med. Genet. 39 (10): E66. doi:10.1136/jmg.39.10.e66. PMC 1734976. PMID 12362048. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1734976.
Cheng CH, Yew DT, Kwan HY, et al. (2003). "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA.". Mol. Biol. Cell 13 (10): 3696–705. doi:10.1091/mbc.E02-03-0127. PMC 129976. PMID 12388767. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129976.
Zhong H, Molday LL, Molday RS, Yau KW (2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry.". Nature 420 (6912): 193–8. doi:10.1038/nature01201. PMC 2877395. PMID 12432397. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2877395.
Zheng J, Trudeau MC, Zagotta WN (2003). "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit.". Neuron 36 (5): 891–6. doi:10.1016/S0896-6273(02)01099-1. PMID 12467592.
Kang K, Bauer PJ, Kinjo TG, et al. (2003). "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs.". Biochemistry 42 (15): 4593–600. doi:10.1021/bi027276z. PMID 12693957.
Zhang Q, Zulfiqar F, Riazuddin SA, et al. (2005). "Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation.". Mol. Vis. 10: 884–9. PMID 15570217.
Shi F, Perez E, Wang T, et al. (2005). "Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis.". J. Androl. 26 (2): 258–63. PMID 15713832.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Voltage-gated	L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3) α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4) Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)

Ligand-gated	Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel (α, β, γ, δ)

Proton gated	Amiloride-sensitive cation channel (1, 2, 3, 4)

Voltage-gated	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)

K⁺: Potassium channel

Voltage-gated	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene

Calcium-activated	BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)

Inward-rectifier	K_ATP · K_ir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)

Tandem pore domain	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other

Cl^-: Chloride channel	ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)

H⁺: Voltage-gated	HVCN1

M⁺: TRP cation channel	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPN · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)

Cyclic nucleotide-gated (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family

Gap junction	Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4)) Innexin

General	Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

Cyclic nucleotide-gated channel alpha 1

Contents

See also

References

Further reading

External links