CLIP2

CAP-GLY domain containing linker protein 2

PDB rendering based on 2cp2.

Available structures
PDB	2CP2, 2CP3

Identifiers

Symbols

CLIP2; CLIP; CLIP-115; CYLN2; KIAA0291; MGC11333; WBSCR3; WBSCR4; WSCR3; WSCR4

External IDs

OMIM: 603432 MGI: 1313136 HomoloGene: 20718 GeneCards: CLIP2 Gene

Gene Ontology
Molecular function	• microtubule plus-end binding
Cellular component	• cytoplasm • cytoskeleton • microtubule associated complex • cytoplasmic microtubule
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
73.7 – 73.82 Mb

Chr 5:
134.97 – 135.03 Mb

PubMed search

[1]

[2]

CAP-Gly domain-containing linker protein 2 is a protein that in humans is encoded by the CLIP2 gene.^[1]^[2]^[3]

The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.^[3]

References

^ Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460.
^ Hoogenraad CC, Eussen BH, Langeveld A, van Haperen R, Winterberg S, Wouters CH, Grosveld F, De Zeeuw CI, Galjart N (Dec 1998). "The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region". Genomics 53 (3): 348–58. doi:10.1006/geno.1998.5529. PMID 9799601.
^ ^a ^b "Entrez Gene: CLIP2 CAP-GLY domain containing linker protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7461.

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Ohara O, Nagase T, Ishikawa K et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Corper AL, Stratmann T, Apostolopoulos V et al. (2000). "A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes". Science 288 (5465): 505–11. doi:10.1126/science.288.5465.505. PMID 10775108.
Akhmanova A, Hoogenraad CC, Drabek K et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
Hoogenraad CC, Koekkoek B, Akhmanova A et al. (2002). "Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice". Nat. Genet. 32 (1): 116–27. doi:10.1038/ng954. PMID 12195424.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Navarro-Lérida I, Martínez Moreno M, Roncal F et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Evgrafov OV, Mersiyanova I, Irobi J et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy". Nat. Genet. 36 (6): 602–6. doi:10.1038/ng1354. PMID 15122254.
Cheng J, Kapranov P, Drenkow J et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2cp2: Solution structure of the 1st CAP-Gly domain in human CLIP-115/CYLN2

2cp3: Solution structure of the 2nd CAP-Gly domain in human CLIP-115/CYLN2

CLIP2

References

Further reading