CLIP1

CAP-GLY domain containing linker protein 1

PDB rendering based on 2cp5.

Available structures
PDB	2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U

Identifiers

Symbols

CLIP1; CLIP; CLIP-170; CLIP170; CYLN1; MGC131604; RSN

External IDs

OMIM: 179838 MGI: 1928401 HomoloGene: 74455 GeneCards: CLIP1 Gene

Gene Ontology
Molecular function	• nucleic acid binding • protein binding • microtubule binding • zinc ion binding • protein homodimerization activity • metal ion binding • microtubule plus-end binding
Cellular component	• kinetochore • cytoplasm • endosome • centrosome • cytosol • microtubule • cytoplasmic microtubule • intermediate filament • microtubule cytoskeleton
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • mitosis • positive regulation of microtubule polymerization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
122.76 – 122.91 Mb

Chr 5:
124.03 – 124.13 Mb

PubMed search

[1]

[2]

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.^[1]

Interactions

CLIP1 has been shown to interact with IQGAP1,^[2] Mammalian target of rapamycin^[3] and PAFAH1B1.^[4]

References

^ "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6249.
^ Fukata, Masaki; Watanabe Takashi, Noritake Jun, Nakagawa Masato, Yamaga Masaki, Kuroda Shinya, Matsuura Yoshiharu, Iwamatsu Akihiro, Perez Franck, Kaibuchi Kozo (Jun. 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell (United States) 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. ISSN 0092-8674. PMID 12110184.
^ Choi, Jae H; Bertram Paula G, Drenan Ryan, Carvalho John, Zhou Heather H, Zheng X F Steven (Oct. 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Rep. (England) 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. ISSN 1469-221X. PMC 1307618. PMID 12231510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1307618.
^ Coquelle, Frédéric M; Caspi Michal, Cordelières Fabrice P, Dompierre Jim P, Dujardin Denis L, Koifman Cynthia, Martin Patrick, Hoogenraad Casper C, Akhmanova Anna, Galjart Niels, De Mey Jan R, Reiner Orly (May. 2002). "LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway". Mol. Cell. Biol. (United States) 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. ISSN 0270-7306. PMC 133759. PMID 11940666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133759.

Galjart N (2005). "CLIPs and CLASPs and cellular dynamics". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
Pierre P, Scheel J, Rickard JE, Kreis TE (1992). "CLIP-170 links endocytic vesicles to microtubules". Cell 70 (6): 887–900. doi:10.1016/0092-8674(92)90240-D. PMID 1356075.
Bilbe G, Delabie J, Brüggen J, et al. (1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". EMBO J. 11 (6): 2103–13. PMC 556677. PMID 1600942. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556677.
Pierre P, Pepperkok R, Kreis TE (1995). "Molecular characterization of two functional domains of CLIP-170 in vivo". J. Cell. Sci. 107 ( Pt 7): 1909–20. PMID 7983157.
Hilliker C, Delabie J, Speleman F, et al. (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". Cytogenet. Cell Genet. 65 (3): 172–6. doi:10.1159/000133625. PMID 8222754.
Griparic L, Keller TC (1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle". Biochim. Biophys. Acta 1405 (1–3): 35–46. doi:10.1016/S0167-4889(98)00096-2. PMID 9784600.
Perez F, Diamantopoulos GS, Stalder R, Kreis TE (1999). "CLIP-170 highlights growing microtubule ends in vivo". Cell 96 (4): 517–27. doi:10.1016/S0092-8674(00)80656-X. PMID 10052454.
Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
Coquelle FM, Caspi M, Cordelières FP, et al. (2002). "LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway". Mol. Cell. Biol. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133759.
Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen". Clin. Exp. Immunol. 127 (3): 533–8. doi:10.1046/j.1365-2249.2002.01756.x. PMC 1906301. PMID 11966772. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1906301.
Fukata M, Watanabe T, Noritake J, et al. (2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
Choi JH, Bertram PG, Drenan R, et al. (2003). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Rep. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1307618.
Sahin U, Neumann F, Tureci O, et al. (2003). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood 100 (12): 4139–45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Goodson HV, Skube SB, Stalder R, et al. (2004). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". Cell Motil. Cytoskeleton 55 (3): 156–73. doi:10.1002/cm.10114. PMID 12789661.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Watanabe T, Wang S, Noritake J, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Dev. Cell 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.

PDB gallery

2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin

2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

CLIP1

Interactions

References

Further reading