CITED2
Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.[1][2][3]
Interactions
CITED2 has been shown to interact with EP300,[4][5][6][7] LHX2[7] and TFAP2A.[5][6]
References
- ^ Shioda T, Fenner MH, Isselbacher KJ (Dec 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37985.
- ^ Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Feb 2000). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.
- ^ "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10370.
- ^ Bhattacharya, S; Michels C L, Leung M K, Arany Z P, Kung A L, Livingston D M (Jan. 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes Dev. (UNITED STATES) 13 (1): 64–75. doi:10.1101/gad.13.1.64. ISSN 0890-9369. PMC 316375. PMID 9887100. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316375.
- ^ a b Bragança, José; Eloranta Jyrki J, Bamforth Simon D, Ibbitt J Claire, Hurst Helen C, Bhattacharya Shoumo (May. 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". J. Biol. Chem. (United States) 278 (18): 16021–9. doi:10.1074/jbc.M208144200. ISSN 0021-9258. PMID 12586840.
- ^ a b Bragança, José; Swingler Tracey, Marques Fatima I R, Jones Tania, Eloranta Jyrki J, Hurst Helen C, Shioda Toshihiro, Bhattacharya Shoumo (Mar. 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. (United States) 277 (10): 8559–65. doi:10.1074/jbc.M110850200. ISSN 0021-9258. PMID 11744733.
- ^ a b Glenn, D J; Maurer R A (Dec. 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. (UNITED STATES) 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. ISSN 0021-9258. PMID 10593900.
Further reading
- Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (2007). "CITED2 is expressed in human adrenococrtical cells and regulated by basic fibroblast growth factor". J Endocrinol. 192 (2): 459–65. doi:10.1677/JOE-06-0083. PMID 17283246.
- Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
- Sun HB, Zhu YX, Yin T et al. (1998). "MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity". Proc. Natl. Acad. Sci. U.S.A. 95 (23): 13555–60. doi:10.1073/pnas.95.23.13555. PMC 24857. PMID 9811838. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24857.
- Bhattacharya S, Michels CL, Leung MK et al. (1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes Dev. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316375.
- Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
- Bragança J, Swingler T, Marques FI et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bragança J, Eloranta JJ, Bamforth SD et al. (2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". J. Biol. Chem. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
- Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMID 12762840.
- Yokota H, Goldring MB, Sun HB (2004). "CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear". J. Biol. Chem. 278 (47): 47275–80. doi:10.1074/jbc.M304652200. PMID 12960175.
- Bhakat KK, Izumi T, Yang SH et al. (2004). "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene". EMBO J. 22 (23): 6299–309. doi:10.1093/emboj/cdg595. PMC 291836. PMID 14633989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291836.
- Tien ES, Davis JW, Vanden Heuvel JP (2004). "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator". J. Biol. Chem. 279 (23): 24053–63. doi:10.1074/jbc.M401489200. PMID 15051727.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Sperling S, Grimm CH, Dunkel I et al. (2006). "Identification and functional analysis of CITED2 mutations in patients with congenital heart defects". Hum. Mutat. 26 (6): 575–82. doi:10.1002/humu.20262. PMID 16287139.
- Oh JH, Yang JO, Hahn Y et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Chou YT, Yang YC (2006). "Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region". J. Biol. Chem. 281 (27): 18451–62. doi:10.1074/jbc.M601720200. PMID 16675452.
- Qu X, Lam E, Doughman YQ et al. (2007). "Cited2, a coactivator of HNF4α, is essential for liver development". EMBO J. 26 (21): 4445–56. doi:10.1038/sj.emboj.7601883. PMC 2063472. PMID 17932483. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063472.
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PDB gallery
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1r8u: NMR structure of CBP TAZ1/CITED2 complex
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