CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

Identifiers

CITED1; MSG1

External IDs

OMIM: 300149 MGI: 108023 HomoloGene: 3057 GeneCards: CITED1 Gene

Gene Ontology
Molecular function	• chromatin binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • protein binding • protein C-terminus binding • protein homodimerization activity • transcription regulatory region DNA binding • LBD domain binding • co-SMAD binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• metanephros development • branching involved in ureteric bud morphogenesis • placenta development • transcription, DNA-dependent • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • nucleocytoplasmic transport • apoptosis • transforming growth factor beta receptor signaling pathway • multicellular organismal development • cell proliferation • positive regulation of gene expression • cell differentiation • negative regulation of Wnt receptor signaling pathway • melanocyte differentiation • positive regulation of transforming growth factor beta receptor signaling pathway • response to lipopolysaccharide • response to insulin stimulus • response to cytokine stimulus • response to interferon-gamma • melanin biosynthetic process • pigmentation • negative regulation of neuron apoptosis • response to estrogen stimulus • response to estrogen stimulus • negative regulation of osteoblast differentiation • positive regulation of anti-apoptosis • negative regulation of transcription, DNA-dependent • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • response to cAMP • mesenchymal to epithelial transition • SMAD protein signal transduction • response to interleukin-1 • response to interleukin-2 • response to interleukin-4 • response to interleukin-6 • response to interleukin-9 • response to interleukin-11 • response to parathyroid hormone stimulus • response to transforming growth factor beta stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000125931

ENSMUSG00000051159

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
71.52 – 71.53 Mb

Chr X:
99.44 – 99.45 Mb

PubMed search

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.^[1]^[2]^[3]

Interactions

CITED1 has been shown to interact with HSPA8^[4] and EP300.^[4]

References

^ Shioda T, Fenner MH, Isselbacher KJ (Dec 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37985.
^ Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (Oct 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
^ "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4435.
^ ^a ^b Yahata, T; de Caestecker M P, Lechleider R J, Andriole S, Roberts A B, Isselbacher K J, Shioda T (Mar. 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. (UNITED STATES) 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

Further reading

Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain.". Gene 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
Li H, Ahmed NU, Fenner MH, et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
Shioda T, Lechleider RJ, Dunwoodie SL, et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21414.
Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand) 45 (7): 1075–82. PMID 10644012.
Yahata T, de Caestecker MP, Lechleider RJ, et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
Ahmed NU, Shioda T, Coser KR, et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
Yahata T, Shao W, Endoh H, et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312794.
Bragança J, Swingler T, Marques FI, et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Shi G, Boyle SC, Sparrow DB, et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
Lovvorn HN, Westrup J, Opperman S, et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1941694.