CHD5

Chromodomain helicase DNA binding protein 5

PDB rendering based on 1mm2.

Available structures
PDB	1mm2

Identifiers

Symbols

CHD5; DKFZp434N231; KIAA0444

External IDs

OMIM: 610771 MGI: 3036258 HomoloGene: 56712 GeneCards: CHD5 Gene

EC number

3.6.4.12

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • helicase activity • ATP binding • ATP-dependent helicase activity • zinc ion binding • hydrolase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • metal ion binding
Cellular component	• nucleus
Biological process	• regulation of transcription, DNA-dependent • chromatin modification
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
6.16 – 6.24 Mb

Chr 4:
151.71 – 151.76 Mb

PubMed search

[1]

[2]

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.^[1]^[2]^[3]

References

^ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561.
^ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
^ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26038.

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Seki N, Ohira M, Nagase T et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Nagase T, Kikuno R, Ishikawa KI et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bagchi A, Papazoglu C, Wu Y et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567.

PDB gallery

1mm2: Solution structure of the 2nd PHD domain from Mi2b

CHD5

References

Further reading