CHAF1B
Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.[1][2][3]
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.[3]
Interactions
CHAF1B has been shown to interact with BAZ1B,[4] ASF1B[5][6] and ASF1A.[6]
References
- ^ Kaufman PD, Kobayashi R, Kessler N, Stillman B (Aug 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578.
- ^ Katsanis N, Fisher EM (Oct 1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Hum Genet 98 (4): 497–9. doi:10.1007/s004390050246. PMID 8792829.
- ^ a b "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8208.
- ^ Kitagawa, Hirochika; Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki (Jun. 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell (United States) 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. ISSN 0092-8674. PMID 12837248.
- ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- ^ a b Mello, Jill A; Silljé Herman H W, Roche Daniele M J, Kirschner Doris B, Nigg Erich A, Almouzni Geneviève (Apr. 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. (England) 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. ISSN 1469-221X. PMC 1084056. PMID 11897662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084056.
Further reading
- Ridgway P, Almouzni G (2000). "CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair". J. Cell. Sci. 113 ( Pt 15): 2647–58. PMID 10893180.
- Blouin JL, Duriaux-Sail G, Chen H, et al. (1997). "Mapping of the gene for the p60 subunit of the human chromatin assembly factor (CAF1A) to the Down syndrome region of chromosome 21". Genomics 33 (2): 309–12. doi:10.1006/geno.1996.0199. PMID 8660983.
- Verreault A, Kaufman PD, Kobayashi R, Stillman B (1996). "Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4". Cell 87 (1): 95–104. doi:10.1016/S0092-8674(00)81326-4. PMID 8858152.
- Matsumoto-Taniura N, Pirollet F, Monroe R, et al. (1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol. Biol. Cell 7 (9): 1455–69. PMC 275994. PMID 8885239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275994.
- Marheineke K, Krude T (1998). "Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle". J. Biol. Chem. 273 (24): 15279–86. doi:10.1074/jbc.273.24.15279. PMID 9614144.
- Martini E, Roche DM, Marheineke K, et al. (1998). "Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells". J. Cell Biol. 143 (3): 563–75. doi:10.1083/jcb.143.3.563. PMC 2148138. PMID 9813080. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2148138.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
- Keller C, Krude T (2001). "Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis". J. Biol. Chem. 275 (45): 35512–21. doi:10.1074/jbc.M003073200. PMID 10938080.
- Mello JA, Silljé HH, Roche DM, et al. (2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084056.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Morel AP, Sentis S, Bianchin C, et al. (2004). "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms". J. Cell. Sci. 116 (Pt 14): 2929–36. doi:10.1242/jcs.00480. PMID 12771185.
- Nabatiyan A, Krude T (2004). "Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis". Mol. Cell. Biol. 24 (7): 2853–62. doi:10.1128/MCB.24.7.2853-2862.2004. PMC 371118. PMID 15024074. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371118.
- Shim KS, Bergelson JM, Furuse M, et al. (2004). "Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain". J. Neural Transm. Suppl. (67): 117–28. PMID 15068244.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517884.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Groth A, Ray-Gallet D, Quivy JP, et al. (2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Mol. Cell 17 (2): 301–11. doi:10.1016/j.molcel.2004.12.018. PMID 15664198.