Centrosomal protein 170kDa | |||||||||
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Identifiers | |||||||||
Symbols | CEP170; FAM68A; KAB; KIAA0470 | ||||||||
External IDs | OMIM: 613023 MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170 Gene | ||||||||
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Orthologs | |||||||||
Species | Human | Mouse | |||||||
Entrez | 9859 | 545389 | |||||||
Ensembl | ENSG00000143702 | ENSMUSG00000057335 | |||||||
UniProt | Q5SW79 | Q6A065 | |||||||
RefSeq (mRNA) | NM_001042404.1 | NM_001099637.2 | |||||||
RefSeq (protein) | NP_001035863.1 | NP_001093107.2 | |||||||
Location (UCSC) | Chr 1: 243.29 – 243.42 Mb |
Chr 1: 178.66 – 178.74 Mb |
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PubMed search | [1] | [2] |
Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[1][2]
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[1]
The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[1]
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