CEP120

Centrosomal protein 120kDa

Identifiers

CEP120; CCDC100; DKFZp686I06246; FLJ36090; FLJ38327

External IDs

OMIM: 613446 MGI: 2147298 HomoloGene: 27415 GeneCards: CEP120 Gene

Gene Ontology
Molecular function	• protein C-terminus binding
Cellular component	• cytoplasm • centrosome • cytoskeleton
Biological process	• microtubule cytoskeleton organization • cell proliferation • cerebral cortex development • neurogenesis • interkinetic nuclear migration • astral microtubule organization • regulation of protein localization • regulation of microtubule-based process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
122.68 – 122.76 Mb

Chr 18:
53.84 – 53.9 Mb

PubMed search

[1]

[2]

Centrosomal protein of 120 kDa (Cep120), also known as coiled-coil domain-containing protein 100, is a protein that in humans is encoded by the CEP120 gene.^[1]^[2]

Function

This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects.^[1]

References

^ ^a ^b "Entrez Gene: centrosomal protein 120kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153241.
^ Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH (October 2007). "Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool". Neuron 56 (1): 79–93. doi:10.1016/j.neuron.2007.08.026. PMC 2642594. PMID 17920017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2642594.

Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Vasan RS, Glazer NL, Felix JF, et al. (2009). "Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data". JAMA 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2975567.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Guerrier S, Polleux F (2007). "The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration". Neuron 56 (1): 1–3. doi:10.1016/j.neuron.2007.09.019. PMID 17920006.
Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260.

The centrosome and its components

Centrioles	CNTROB · SASS6 · CENPJ

Pericentriolar material	BBS4 · Lck · PCM1 · PCNT · TNKS · TNKS2 · Tubulin

other proteins	CCP110 · CEP55 · CEP57 · CEP63 · CEP68 · CEP70 · CEP72 · CEP76 · CEP78 · CEP90 · CEP97 · CEP120 · CEP135 · CEP152 · CEP164 · CEP170 · CEP192 · CEP215 · CEP250 · CEP350 · CNTRL · NIN · NINL

B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

CEP120

Function

References

Further reading