CENTB1

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Identifiers

ACAP1; CENTB1; KIAA0050

External IDs

OMIM: 607763 MGI: 2388270 HomoloGene: 22835 GeneCards: ACAP1 Gene

Gene Ontology
Molecular function	• phospholipase C activity • protein binding • ARF GTPase activator activity • zinc ion binding • metal ion binding
Biological process	• lipid metabolic process • protein transport • regulation of ARF GTPase activity • intracellular signal transduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
7.24 – 7.25 Mb

Chr 11:
69.7 – 69.71 Mb

PubMed search

[1]

[2]

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ACAP1 gene.^[1]^[2]^[3]

References

^ Jackson TR, Kearns BG, Theibert AB (Dec 2000). "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling". Trends Biochem Sci 25 (10): 489–95. doi:10.1016/S0968-0004(00)01644-3. PMID 11050434.
^ Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol 151 (3): 627–38. doi:10.1083/jcb.151.3.627. PMC 2185579. PMID 11062263. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2185579.
^ "Entrez Gene: CENTB1 centaurin, beta 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9744.

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Dai J, Li J, Bos E, et al. (2004). "ACAP1 promotes endocytic recycling by recognizing recycling sorting signals.". Dev. Cell 7 (5): 771–6. doi:10.1016/j.devcel.2004.10.002. PMID 15525538.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Yamamoto-Furusho JK, Barnich N, Xavier R, et al. (2007). "Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.". J. Biol. Chem. 281 (47): 36060–70. doi:10.1074/jbc.M602383200. PMID 17005562.
Shinozaki-Narikawa N, Kodama T, Shibasaki Y (2007). "Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulation.". Traffic 7 (11): 1539–50. doi:10.1111/j.1600-0854.2006.00480.x. PMID 17010122.
Li J, Peters PJ, Bai M, et al. (2007). "An ACAP1-containing clathrin coat complex for endocytic recycling.". J. Cell Biol. 178 (3): 453–64. doi:10.1083/jcb.200608033. PMC 2064835. PMID 17664335. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2064835.

CENTB1

References

Further reading